School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin Veterinary Care, University of Wisconsin-Madison, Madison WI, USA.
J Feline Med Surg. 2024 Oct;26(10):1098612X241254024. doi: 10.1177/1098612X241254024.
The study aimed to describe the clinical use of chloramphenicol in client-owned cats, examining the patient population, sites of infection, targeted pathogens, prescribed dosing regimen, outcomes and adverse effects.
Between 2015 and 2023, a retrospective medical record review was undertaken to identify a case series of cats treated with chloramphenicol.
Twelve client-owned cats with complicated infections were treated with chloramphenicol at a median dose of 13.3 mg/kg (range 9.1-34.7) administered orally every 12 h for a median duration of 14.5 days. Within 30 days before starting chloramphenicol, 11/12 cats had received treatment with at least one antibiotic. The sites of infection included skin, urinary tract and multisystemic. Multidrug-resistant pathogens, for which no alternative oral antibiotic therapy was available, were commonly targeted. These included meticillin-resistant species and multidrug-resistant . Of the 12 cats treated with chloramphenicol, nine effectively achieved either bacteriologic or clinical cure. Chloramphenicol adverse effects were uncommon and limited to gastrointestinal upset, which was self-limiting or manageable with supportive treatment in two cats.
In these cats, the decision to treat with chloramphenicol was made because an alternative oral antibiotic was not available to target the multidrug-resistant pathogens. Infections of the skin or urinary tract were common. Overall, chloramphenicol was well tolerated, and treatment success was possible for most cats.
本研究旨在描述氯霉素在患宠猫中的临床应用，分析患者人群、感染部位、目标病原体、规定的给药方案、结果和不良反应。
在 2015 年至 2023 年间，进行了一项回顾性病历审查，以确定一系列接受氯霉素治疗的猫的病例系列。
12 只患有复杂感染的患宠猫以 13.3mg/kg（范围 9.1-34.7）的中位数剂量经口给予氯霉素，每 12 小时给药一次，中位数疗程为 14.5 天。在开始使用氯霉素的 30 天前，11/12 只猫接受了至少一种抗生素的治疗。感染部位包括皮肤、泌尿道和多系统。针对多药耐药病原体，通常选择无其他口服抗生素治疗的药物。这些病原体包括耐甲氧西林的 和多药耐药的 。在接受氯霉素治疗的 12 只猫中，有 9 只有效实现了细菌学或临床治愈。氯霉素不良反应罕见，仅限于胃肠道不适，在 2 只猫中，胃肠道不适为自限性或经支持治疗即可控制。
在这些猫中，决定使用氯霉素治疗是因为没有其他可用于靶向多药耐药病原体的口服抗生素。皮肤或泌尿道感染很常见。总体而言，氯霉素耐受性良好，大多数猫的治疗效果良好。
