Brugere J, Guenel P, Leclerc A, Rodriguez J
Cancer. 1986 Jan 15;57(2):391-5. doi: 10.1002/1097-0142(19860115)57:2<391::aid-cncr2820570235>3.0.co;2-q.
Two thousand five hundred forty male patients with cancer of larynx, pharynx, and mouth were examined in the same hospital between 1975 and 1982. Different sites were compared according to alcohol and tobacco consumption: oropharynx, hypopharynx, larynx supraglottis, larynxglottis, epilarynx, lip, tongue-tip, and tongue lateral border, other tongue sites, gum, floor of the mouth, and buccal mucosa. For tobacco, the mean daily consumption of smokers and exsmokers did not differ according to location (except in patients with cancer of the lip, in whom the consumption was lowest). Cancer locations differed significantly according to the daily alcohol consumption. The consumption was the lowest for patients with cancer of the lips and the glottis, the highest for patients with cancer of the epilarynx, hypopharynx, and the floor of the mouth. Significant differences were observed in the percentage of nonsmokers or nondrinkers, even between adjacent locations: supraglottis versus glottis; tongue, tip, and lateral border versus tongue, other sites; floor of the mouth versus buccal mucosa. Some of the results might be particular to elements of the French life-style (e.g., consumption of brown tobacco, high consumption of wine).
1975年至1982年间，同一家医院对2540名患有喉癌、咽癌和口腔癌的男性患者进行了检查。根据酒精和烟草的摄入量对不同部位进行了比较：口咽、下咽、喉声门上区、喉声门区、喉上区、唇、舌尖、舌外侧缘、舌其他部位、牙龈、口底和颊黏膜。就烟草而言，吸烟者和已戒烟者的平均每日摄入量根据部位不同并无差异（唇部癌症患者除外，其摄入量最低）。癌症部位根据每日酒精摄入量的不同而有显著差异。唇部和声门区癌症患者的酒精摄入量最低，喉上区、下咽和口底癌症患者的酒精摄入量最高。即使在相邻部位之间，非吸烟者或非饮酒者的比例也存在显著差异：声门上区和声门区；舌尖和舌外侧缘与舌其他部位；口底和颊黏膜。其中一些结果可能与法国生活方式的某些因素有关（例如，吸食棕色烟草、葡萄酒消费量高）。
