纤维连接蛋白在发育和伤口愈合中的作用。
Fibronectin in development and wound healing.
机构信息
Department of Bioengineering, Temple University, Philadelphia, PA, USA.
Department of Bioengineering, Temple University, Philadelphia, PA, USA.
出版信息
Adv Drug Deliv Rev. 2021 Mar;170:353-368. doi: 10.1016/j.addr.2020.09.005. Epub 2020 Sep 19.
Fibronectin structure and composition regulate contextual cell signaling. Recent advances have been made in understanding fibronectin and its role in tissue organization and repair. This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin, and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing.
纤连蛋白的结构和组成调节上下文细胞信号。最近在理解纤连蛋白及其在组织组织和修复中的作用方面取得了进展。本综述概述了纤连蛋白剪接变体及其功能，评估了针对或利用纤连蛋白的潜在治疗策略，并通过讨论在发育和伤口愈合中调节纤连蛋白功能的潜在未来方向来结束。
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