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含有无碱基残基的十三聚核苷酸的核磁共振、圆二色光谱和红外光谱：B构象和Z构象的共存

NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations.

作者信息

Pochet S, Huynh-Dinh T, Neumann J M, Tran-Dinh S, Adam S, Taboury J, Taillandier E, Igolen J

出版信息

Nucleic Acids Res. 1986 Jan 24;14(2):1107-26. doi: 10.1093/nar/14.2.1107.

DOI:10.1093/nar/14.2.1107
PMID:3945553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339486/
Abstract

The synthesis of the tridecadeoxynucleotide d(CGm5CGCGxACATGT), where x is the 1-cyano-2-deoxy-beta-D-erythropentofuranose, is described. The NMR, IR, CD studies at various salt concentrations and temperatures of this oligomer show that the B and Z conformations are simultaneously present in the same short DNA fragment. A single apurinic residue is sufficient for the coexistence of the B and Z helices on this oligomer.

摘要

描述了十三聚脱氧核苷酸d（CGm5CGCGxACATGT）的合成，其中x为1-氰基-2-脱氧-β-D-赤藓戊呋喃糖。对该寡聚物在不同盐浓度和温度下的核磁共振（NMR）、红外光谱（IR）、圆二色光谱（CD）研究表明，B型和Z型构象同时存在于同一短DNA片段中。单个脱嘌呤残基足以使该寡聚物上的B型和Z型螺旋共存。

相似文献

1
NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations.含有无碱基残基的十三聚核苷酸的核磁共振、圆二色光谱和红外光谱：B构象和Z构象的共存
Nucleic Acids Res. 1986 Jan 24;14(2):1107-26. doi: 10.1093/nar/14.2.1107.
2
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Temperature-dependent CD and NMR studies on a synthetic oligonucleotide containing a B-Z junction at high salt.在高盐条件下对含有B-Z连接的合成寡核苷酸进行的温度依赖性圆二色光谱和核磁共振研究。
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引用本文的文献

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2
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3
Synthesis, thermal stability and reactivity towards 9-aminoellipticine of double-stranded oligonucleotides containing a true abasic site.含有真实无碱基位点的双链寡核苷酸的合成、热稳定性及对9-氨基玫瑰树碱的反应活性
Nucleic Acids Res. 1989 Dec 25;17(24):10307-19. doi: 10.1093/nar/17.24.10307.

本文引用的文献

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Structural transitions in DNAs and nucleohistones studied by I.R. spectroscopy.通过红外光谱研究DNA和核组蛋白中的结构转变。
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7-Methylguanine in poly(dG-dC).poly(dG-dC) facilitates z-DNA formation.聚（dG-dC）·聚（dG-dC）中的7-甲基鸟嘌呤促进Z-DNA的形成。
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Spectroscopic studies of (m5dC-dG)3: thermal stability of B- and Z-forms.（m5dC-dG）3的光谱研究：B型和Z型的热稳定性
Nucleic Acids Res. 1983 Jul 11;11(13):4453-66. doi: 10.1093/nar/11.13.4453.
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Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes.抗左旋Z-DNA的抗体与果蝇多线染色体的间带区域结合。
Nature. 1981 Dec 3;294(5840):417-22. doi: 10.1038/294417a0.
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Experimental and calculated study of the vibrational modes of poly(dG-dC).poly(dG-dC) in B and Z conformations.聚（dG-dC）·聚（dG-dC）在B构象和Z构象中振动模式的实验与计算研究
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Interaction of Z form poly(dG-dC).poly(dG-dC) with divalent metal ions: localization of the binding sites by I.R. spectroscopy.Z型聚（dG-dC）·聚（dG-dC）与二价金属离子的相互作用：通过红外光谱法确定结合位点的位置
Nucleic Acids Res. 1984 May 25;12(10):4247-58. doi: 10.1093/nar/12.10.4247.
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Sequential resonance assignments in 1H NMR spectra of oligonucleotides by two-dimensional NMR spectroscopy.通过二维核磁共振光谱对寡核苷酸的1H NMR光谱进行顺序共振归属。
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