含有无碱基残基的十三聚核苷酸的核磁共振、圆二色光谱和红外光谱：B构象和Z构象的共存
NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations.
作者信息
Pochet S, Huynh-Dinh T, Neumann J M, Tran-Dinh S, Adam S, Taboury J, Taillandier E, Igolen J
出版信息
Nucleic Acids Res. 1986 Jan 24;14(2):1107-26. doi: 10.1093/nar/14.2.1107.
Abstract
The synthesis of the tridecadeoxynucleotide d(CGm5CGCGxACATGT), where x is the 1-cyano-2-deoxy-beta-D-erythropentofuranose, is described. The NMR, IR, CD studies at various salt concentrations and temperatures of this oligomer show that the B and Z conformations are simultaneously present in the same short DNA fragment. A single apurinic residue is sufficient for the coexistence of the B and Z helices on this oligomer.
摘要
描述了十三聚脱氧核苷酸d（CGm5CGCGxACATGT）的合成，其中x为1-氰基-2-脱氧-β-D-赤藓戊呋喃糖。对该寡聚物在不同盐浓度和温度下的核磁共振（NMR）、红外光谱（IR）、圆二色光谱（CD）研究表明，B型和Z型构象同时存在于同一短DNA片段中。单个脱嘌呤残基足以使该寡聚物上的B型和Z型螺旋共存。
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7-Methylguanine in poly(dG-dC).poly(dG-dC) facilitates z-DNA formation.聚（dG-dC）·聚（dG-dC）中的7-甲基鸟嘌呤促进Z-DNA的形成。
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