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守护大脑:颅骨干细胞与脑边界免疫

Guardians of the mind: Calvarial stem cells and brain border immunity.

机构信息

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Ren Min Nan Road, Chengdu, Sichuan 610041, China.

出版信息

Stem Cell Reports. 2024 Nov 12;19(11):1520-1523. doi: 10.1016/j.stemcr.2024.10.002. Epub 2024 Oct 31.

Abstract

Calvarial bones safeguard the brain and are interconnected by immovable joints termed sutures, which function as growth centers for skull morphogenesis and stem cell niches. Recent years have witnessed paradigm shifts in this field, highlighting the essential roles of calvarial stem cells (CSCs), sutures, and surrounding structures in neuroimmune crosstalk and neurocognitive restoration.

摘要

颅骨保护大脑,并通过被称为缝合线的不可移动关节相互连接,这些关节作为颅骨形态发生和干细胞龛的生长中心发挥作用。近年来,该领域发生了范式转变,强调了颅骨干细胞(CSC)、缝合线和周围结构在神经免疫串扰和神经认知恢复中的重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a4a/11589192/862a201fe526/gr1.jpg

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