Kennedy R C, Eichberg J W, Lanford R E, Dreesman G R
Science. 1986 Apr 11;232(4747):220-3. doi: 10.1126/science.3952505.
Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity appeared to be against the anti-Id, since the anti-Id immunogen was shown to bind the chimpanzee anti-HBs. Two chimpanzees immunized with the anti-Id, along with two control animals that were either untreated or received a nonimmune rabbit immunoglobulin G preparation, were challenged with infectious hepatitis B virus. Both control chimpanzees developed clinical and serological characteristics consistent with an active hepatitis B virus infection, whereas the two anti-Id treated chimpanzees were protected from infection. Since chimpanzees provide a relevant model of a human response to hepatitis B virus immunization and infection, these results indicate that anti-Id preparations such as that described here might be candidates for vaccines against human diseases.
含有模拟乙型肝炎病毒（HBsAg）表面抗原的内影像成分的抗独特型抗体（抗Id）被用于免疫黑猩猩。四次注射兔抗Id制剂引发了针对HBsAg的抗体反应（抗-HBs）。抗体特异性似乎是针对抗Id的，因为抗Id免疫原被证明能结合黑猩猩的抗-HBs。用抗Id免疫的两只黑猩猩，以及两只未治疗或接受非免疫兔免疫球蛋白G制剂的对照动物，接受了传染性乙型肝炎病毒的攻击。两只对照黑猩猩出现了与活动性乙型肝炎病毒感染一致的临床和血清学特征，而两只接受抗Id治疗的黑猩猩则受到了感染保护。由于黑猩猩提供了人类对乙型肝炎病毒免疫和感染反应的相关模型，这些结果表明，此处所述的抗Id制剂可能是人类疾病疫苗的候选物。
