Panee Jun, Qin Yujia, Deng Youping
Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Microorganisms. 2024 Nov 6;12(11):2244. doi: 10.3390/microorganisms12112244.
The legalization of marijuana (MJ) for medicinal and recreational use has raised concerns about its potential impact on health, including oral health. While MJ use has been linked to poor oral health, its effects on the composition of the oral microbiome remain unclear. This cross-sectional study analyzed saliva samples from chronic MJ users (n = 18) and nonusers (n = 20) to investigate MJ-related changes in salivary microbiome composition. We identified significant differences in the relative abundance of 16 taxa, including seven species, such as , , and . Additionally, five species showed positive correlations with cumulative lifetime MJ use, including and . By grouping salivary microbial communities into clusters based on their association with periodontal health, we found that the cluster with species associated with poor periodontal health had the highest percentage of MJ users. Moreover, MJ use significantly contributed to variance in microbial communities in individuals with relatively good periodontal health. These findings suggest that chronic MJ use is associated with alterations in the salivary microbiome, highlighting its potential broader impact on oral and systemic health.
大麻用于医疗和娱乐用途的合法化引发了人们对其对健康潜在影响的担忧，包括口腔健康。虽然使用大麻与口腔健康不佳有关，但其对口腔微生物群组成的影响仍不清楚。这项横断面研究分析了慢性大麻使用者（n = 18）和非使用者（n = 20）的唾液样本，以调查与大麻相关的唾液微生物群组成变化。我们确定了16个分类群相对丰度的显著差异，包括7个物种，如 、 和 。此外，5个物种与大麻的累积终身使用呈正相关，包括 和 。通过根据唾液微生物群落与牙周健康的关联将其分组为簇，我们发现与牙周健康不佳相关物种的簇中，大麻使用者的比例最高。此外，使用大麻对牙周健康相对较好的个体的微生物群落差异有显著贡献。这些发现表明，长期使用大麻与唾液微生物群的改变有关，凸显了其对口腔和全身健康潜在的更广泛影响。
