Obál F, Sáry G, Alföldi P, Rubicsek G, Obál F
Neurosci Lett. 1986 Feb 28;64(2):236-40. doi: 10.1016/0304-3940(86)90107-2.
The possible sleep-promoting activity of vasoactive intestinal polypeptide (VIP) was contrasted with the physiological sleep suppression in the diurnal active period through the i.c.v. injection of 100 ng VIP into rats at dark onset. The sleep-wake activity and brain temperature (Tbr) were recorded for 24 h (dark period and light period, 12 h each), and the effects were evaluated with respect to records obtained after artificial cerbrospinal fluid injection. Without altering the normal course of Tbr, VIP induced a prompt and persistent increase of sleep. Wakefulness was significantly suppressed and non-REM sleep increased for 6 h, while REM sleep increased for 3 h. The obvious sleep-promoting action of VIP, unrelated to thermoregulatory effects, supports the notion that the peptide might be involved in sleep regulation.
通过在黑暗开始时向大鼠脑室内注射100纳克血管活性肠肽（VIP），将其可能的促睡眠活性与昼间活动期的生理性睡眠抑制进行了对比。记录睡眠-觉醒活动和脑温（Tbr）24小时（黑暗期和光照期各12小时），并根据注射人工脑脊液后获得的记录评估其效果。在不改变Tbr正常变化过程的情况下，VIP引起睡眠迅速且持续增加。觉醒显著受到抑制，非快速眼动睡眠增加6小时，而快速眼动睡眠增加3小时。VIP明显的促睡眠作用与体温调节效应无关，支持了该肽可能参与睡眠调节的观点。
