Zasada Magdalena, Karcz Paulina, Olszewska Marta, Kowalik Aleksandra, Zasada Wojciech, Herman-Sucharska Izabela, Kwinta Przemko
Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
Department of Electroradiology, Jagiellonian University Medical College, Faculty of Health Sciences, Krakow, Poland.
J Perinatol. 2025 Feb;45(2):194-201. doi: 10.1038/s41372-024-02172-2. Epub 2024 Nov 28.
Magnetic resonance spectroscopy (H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.
46 very preterm infants (VP) were evaluated by magnetic resonance imaging and H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.
The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate/ N-acetyl aspartate and Lactate/Creatine ratios than HIE group.
There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.
磁共振波谱（氢质子磁共振波谱，H-MRS）可能会提供有关调控早产儿脑损伤进程的代谢过程的临床相关数据。
对46名极早产儿（VP）在足月相当年龄时进行磁共振成像和H-MRS评估。根据Kidokoro量表评估脑损伤情况。此外，对17名足月出生的缺氧缺血性脑病（HIE）婴儿进行扫描。从中枢神经系统的双侧丘脑获取代谢谱。
中度+重度脑损伤的VP婴儿与无脑损伤的VP婴儿之间，脂质/肌酸、胆碱/肌酸、N-乙酰天门冬氨酸/胆碱、乳酸/N-乙酰天门冬氨酸以及乳酸/肌酸的比值存在差异。此外，中度+重度脑损伤的VP婴儿的乳酸/N-乙酰天门冬氨酸和乳酸/肌酸比值高于HIE组。
有脑损伤和无脑损伤的VP婴儿在足月相当年龄时脑代谢物谱存在显著差异。中度+重度脑损伤的VP婴儿的H-MRS谱可能反映了深刻的慢性代谢改变。
