针对新出现的H5N1高致病性禽流感病毒疫情的有效疫苗的大流行防范。
Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus.
作者信息
Gao Feixia, Wang Qi, Qiu Chenchen, Luo Jian, Li Xiuling
机构信息
Shanghai Institute of Biological Products, 200052, Shanghai, China.
Shanghai Institute of Biological Products, 200052, Shanghai, China.
出版信息
Virol Sin. 2024 Dec;39(6):981-985. doi: 10.1016/j.virs.2024.11.005. Epub 2024 Nov 30.
• Analyzed the outbreak situation and viral characteristics of the newly H5N1 highly pathogenic avian influenza (HPAI) virus. • The current approval and research and development of the H5N1 HPAI vaccines were summarized. • Proposed vaccine development approaches against newly H5N1 virus, e.g. adjuvanted vaccine, mRNA vaccine, multivalent vaccine. • Discussed other prevention and control strategies, e.g. poultry vaccination, global surveillance and comprehensive testing.
• 分析了新型H5N1高致病性禽流感（HPAI）病毒的暴发情况和病毒特征。
• 总结了H5N1 HPAI疫苗目前的获批情况及研发进展。
• 提出了针对新型H5N1病毒的疫苗研发方法，如佐剂疫苗、mRNA疫苗、多价疫苗。
• 讨论了其他防控策略，如家禽疫苗接种、全球监测和全面检测。
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