Sarić M, Godnić-Cvar J, Gomzi M, Stilinović L
Am J Ind Med. 1986;9(3):239-42. doi: 10.1002/ajim.4700090306.
A study was performed to clarify a possible role of atopy in the occurrence of acute bronchoconstrictive impairment observed in some workers in a plant using the Alu-Swiss process for the electrolytic extraction of aluminum. Of 227 workers examined the percentage of those with a history of atopy and positive skin tests for common allergens was within the expected range. Six had positive patch test with 2% NaF. Among seven workers with paroxysmal wheezing and dyspnea, of whom three were only light smokers, three had positive skin test with common allergens but only one of them had an increased IgE value. The same worker also had positive patch test for 2% NaF. The average age of workers with paroxysmal wheezing and dyspnea was 32.6 years, and only two had symptoms defined as chronic bronchitis. Although their forced expiratory volumes, with two exceptions, measured at the beginning of work shift were within normal limits, in most of those workers bronchial hyperreactivity was also objectively assessed using nonspecific bronchoprovocative tests with histamine (or metacholine). The results support our previous findings that acute respiratory impairment in some workers is most probably based on bronchial hyperreactivity and not on an allergic mechanism.
进行了一项研究，以阐明特应性在使用铝电解提取的Alu-Swiss工艺的工厂中一些工人所观察到的急性支气管收缩性损伤发生中的可能作用。在接受检查的227名工人中，有特应性病史且对常见过敏原皮肤试验呈阳性的工人百分比在预期范围内。6人对2%氟化钠斑贴试验呈阳性。在7名阵发性喘息和呼吸困难的工人中，其中3人只是轻度吸烟者，3人对常见过敏原皮肤试验呈阳性，但其中只有1人IgE值升高。同一工人对2%氟化钠斑贴试验也呈阳性。阵发性喘息和呼吸困难工人的平均年龄为32.6岁，只有2人有被定义为慢性支气管炎的症状。尽管除2人外，他们在轮班开始时测量的用力呼气量在正常范围内，但在大多数这些工人中，也使用组胺（或乙酰甲胆碱）非特异性支气管激发试验客观评估了支气管高反应性。结果支持我们之前的发现，即一些工人的急性呼吸损伤很可能基于支气管高反应性而非过敏机制。
