Iwasaka T, Hayashi Y, Yokoyama M, Hachisuga T, Sugimori H
Department of Obstetrics and Gynecology, Saga Medical School, Japan.
Gynecol Oncol. 1990 Apr;37(1):96-102. doi: 10.1016/0090-8258(90)90316-d.
Eight patients with cervical intraepithelial neoplasia (CIN) were administered perilesional injections of human recombinant interferon gamma (IFN-gamma), and the response was evaluated by colposcopy and exfoliative cytology and then by histopathology. In all patients, colposcopic and cytologic findings improved after two to four injections of IFN-gamma and the cytologic findings reverted to normal in five of these eight patients. All five were free of dysplastic lesions. The other three patients with positive cytology and positive colposcopy after completion of IFN-gamma treatment underwent hysterectomy or laser conization, and histopathologic examination revealed residual dysplastic lesions. On the other hand, a control study revealed that only one of eight patients showed spontaneous regression during the 3-month observation period. During the course of these treatments, keratinizing cells were often present in the cervical smears and isolated cell keratinization was often evident in the residual dysplastic lesions of the surgical specimens. These observations suggest that IFN-gamma treatment is an effective therapeutic method for CIN lesions and that IFN-gamma has the potential to differentiate nonkeratinizing squamous cells into keratinizing cells.
对8例宫颈上皮内瘤变（CIN）患者进行病灶周围注射人重组干扰素γ（IFN-γ），通过阴道镜检查和脱落细胞学检查，然后通过组织病理学评估反应。所有患者在注射2至4次IFN-γ后，阴道镜和细胞学检查结果均有改善，这8例患者中有5例细胞学检查结果恢复正常。所有5例均无发育异常病变。另外3例在完成IFN-γ治疗后细胞学检查和阴道镜检查呈阳性的患者接受了子宫切除术或激光锥切术，组织病理学检查显示有残留的发育异常病变。另一方面，一项对照研究显示，在3个月的观察期内，8例患者中只有1例出现自发消退。在这些治疗过程中，宫颈涂片常出现角化细胞，手术标本的残留发育异常病变中常可见孤立的细胞角化。这些观察结果表明，IFN-γ治疗是CIN病变的一种有效治疗方法，并且IFN-γ有将非角化鳞状细胞分化为角化细胞的潜力。
