Enhancing interpretability and accuracy of AI models in healthcare: a comprehensive review on challenges and future directions.

Artificial Intelligence (AI) has demonstrated exceptional performance in automating critical healthcare tasks, such as diagnostic imaging analysis and predictive modeling, often surpassing human capabilities. The integration of AI in healthcare promises substantial improvements in patient outcomes, including faster diagnosis and personalized treatment plans. However, AI models frequently lack interpretability, leading to significant challenges concerning their performance and generalizability across diverse patient populations. These opaque AI technologies raise serious patient safety concerns, as non-interpretable models can result in improper treatment decisions due to misinterpretations by healthcare providers. Our systematic review explores various AI applications in healthcare, focusing on the critical assessment of model interpretability and accuracy. We identify and elucidate the most significant limitations of current AI systems, such as the black-box nature of deep learning models and the variability in performance across different clinical settings. By addressing these challenges, our objective is to provide healthcare providers with well-informed strategies to develop innovative and safe AI solutions. This review aims to ensure that future AI implementations in healthcare not only enhance performance but also maintain transparency and patient safety.