BACKGROUND

Acute coronary syndromes (ACS) require prompt diagnosis through initial electrocardiograms (ECG), but ECG machines are not always accessible. Meanwhile, smartwatches offering ECG functionality have become widespread. This study evaluates the feasibility of an image-based ECG analysis artificial intelligence (AI) system with smartwatch-based multichannel, asynchronous ECG for diagnosing ACS.

METHODS

Fifty-six patients with ACS and 15 healthy participants were included, and their standard 12-lead and smartwatch-based 9-lead ECGs were analyzed. The ACS group was categorized into ACS with acute total occlusion (ACS-O(+), culprit stenosis ≥ 99 %, n = 44) and ACS without occlusion (ACS-O(-), culprit stenosis 70 % to < 99 %, n = 12) based on coronary angiography. A deep learning-based AI-ECG tool interpreting 2-dimensional ECG images generated probability scores for ST-elevation myocardial infarction (qSTEMI), ACS (qACS), and myocardial injury (qMI: troponin I > 0.1 ng/mL).

RESULTS

The AI-driven qSTEMI, qACS, and qMI demonstrated correlation coefficients of 0.882, 0.874, and 0.872 between standard and smartwatch ECGs (all  < 0.001). The qACS score effectively distinguished ACS-O(±) from control, with AUROC for both ECGs (0.991 for standard and 0.987 for smartwatch, P = 0.745). The AUROC of qSTEMI in identifying ACS-O(+) from control was 0.989 and 0.982 with 12-lead and smartwatch ( = 0.617). Discriminating ACS-O(+) from ACS-O(-) or control presented a slight challenge, with an AUROC for qSTEMI of 0.855 for 12-lead and 0.880 for smartwatch ECGs ( = 0.352).

CONCLUSION

AI-ECG scores from standard and smartwatch-based ECGs showed high concordance with comparable diagnostic performance in differentiating ACS-O(+) and ACS-O(-). With increasing accessibility smartwatch accessibility, they may hold promise for aiding ACS diagnosis, regardless of location.