细胞外冷诱导RNA结合蛋白作为慢性阻塞性肺疾病合并肺动脉高压时内皮功能障碍的预测标志物。

The extracellular CIRP as a predictive marker for the endothelial dysfunction in chronic obstructive pulmonary disease combined with pulmonary hypertension.

作者信息

Yao Yun, Jiang Haibo, Xu Dalin, Zhang Bing, Yao Feng, Guo Wei

机构信息

Department of Respiratory and Critical Care Medicine, Anhui Provincial Lujiang County People's Hospital, Hefei, Anhui, P.R. China.

Department of Internal Medicine, Taizhou People's Hospital, Taizhou, Jiangsu, P.R. China.

出版信息

BMC Pulm Med. 2024 Dec 18;24(1):615. doi: 10.1186/s12890-024-03416-9.

DOI:10.1186/s12890-024-03416-9

PMID:39695535

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11656910/

Abstract

BACKGROUND

Pulmonary hypertension (PH) is a serious complication of chronic obstructive pulmonary disease (COPD), distinguished by pulmonary endothelial dysfunction. The extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern (DAMP) that triggers inflammation and causes vascular endothelial dysfunction in COPD-PH.

METHODS

The expression levels of CIRP were compared in peripheral lung tissues among 40 individuals. Moreover, A prospective analysis was conducted on serum levels of eCIRP, interleukin (IL) 1β, IL-33, endothelin-1 (ET-1), and nitric oxide (NO) in 150 COPD patients and 50 healthy control individuals at Jiangsu Taizhou Peoples Hospital. The study aimed to compare these serum levels and correlations among COPD-PH group, COPD non-PH group and the normal group.

RESULTS

We found higher CIRP levels in COPD-PH compared to COPD non-PH and the normal in lung tissue samples. A prospective analysis showed higher serum levels of eCIRP, IL-1β, IL-33, and ET 1 in COPD-PH, while a noticeable reduction in NO levels. There exists a correlation between the severity of COPD-PH and elevated levels of eCIRP, proinflammatory cytokines like IL-1β and IL-33, along with indicators of endothelial dysfunction like endothelin-1 ET-1 and NO. Moreover, the serum eCIRP level demonstrated a notable positive correlation with the levels of IL-1β, IL-33, PCT, and ET-1, while displaying a negative correlation with NO and Peripheral Oxygen Saturation (SpO). Moreover, the serum eCIRP level demonstrated a notable positive correlation with the levels of IL-1β, IL-33, PCT, and ET-1, while displaying a negative correlation with NO and SpO. Moreover, an assessment of independent risk factors for COPD-PH with ROC curve analysis, gauged the predictive value of serum eCIRP, IL-1β, IL-33, ET-1, and NO levels in diagnosing COPD-PH. Elevated eCIRP, IL-33, and ET-1 levels significantly correlated with COPD-PH, highlighting eCIRP's strong predictive value for this condition.

CONCLUSION

eCIRP levels could serve as a valuable biomarker for predicting endothelial dysfunction in COPD-PH.

摘要

背景

肺动脉高压（PH）是慢性阻塞性肺疾病（COPD）的一种严重并发症，其特征为肺内皮功能障碍。细胞外冷诱导RNA结合蛋白（eCIRP）是一种损伤相关分子模式（DAMP），可引发炎症并导致COPD-PH中的血管内皮功能障碍。

方法

比较了40名个体外周肺组织中CIRP的表达水平。此外，对江苏泰州人民医院150例COPD患者和50名健康对照者的血清eCIRP、白细胞介素（IL）-1β、IL-33、内皮素-1（ET-1）和一氧化氮（NO）水平进行了前瞻性分析。该研究旨在比较COPD-PH组、COPD非PH组和正常组的这些血清水平及其相关性。

结果

我们发现，与COPD非PH组和正常组相比，COPD-PH组肺组织样本中的CIRP水平更高。前瞻性分析显示，COPD-PH组血清eCIRP、IL-1β、IL-33和ET-1水平较高，而NO水平显著降低。COPD-PH的严重程度与eCIRP、IL-1β和IL-•33等促炎细胞因子水平升高以及内皮功能障碍指标内皮素-1（ET-1）和NO之间存在相关性。此外，血清eCIRP水平与IL-1β、IL-33、降钙素原（PCT）和ET-1水平呈显著正相关，而与NO和外周血氧饱和度（SpO）呈负相关。此外，血清eCIRP水平与IL-1β、IL-33、PCT和ET-1水平呈显著正相关，而与NO和SpO呈负相关。此外，通过ROC曲线分析评估COPD-PH的独立危险因素，评估血清eCIRP、IL-1β、IL-33、ET-1和NO水平在诊断COPD-PH中的预测价值。eCIRP、IL-33和ET-1水平升高与COPD-PH显著相关，突出了eCIRP对该疾病的强大预测价值。