中毒性休克综合征毒素1对鸡胚的影响。
Effect of toxic shock syndrome toxin 1 on chicken embryos.
作者信息
de Azavedo J C, Lucken R N, Arbuthnott J P
出版信息
Infect Immun. 1985 Mar;47(3):710-2. doi: 10.1128/iai.47.3.710-712.1985.
Abstract
Staphylococcus aureus strains associated with toxic shock syndrome produce toxic shock syndrome toxin 1 (TSST1). This toxin has a variety of biological effects, including enhanced lethality in rabbits in the presence of sublethal amounts of lipopolysaccharide (LPS). Because chicken embryos are highly susceptible to LPS, the synergistic effect of TSST1 and LPS was examined in this system. Although TSST1 per se had no effect on chicken embryos, it potentiated the lethal effect of LPS. The 50% lethal dose of LPS was greatly reduced in the presence of up to 10 micrograms of TSST1 per ml. However, at high doses of TSST1 (greater than 100 micrograms/ml), no enhanced lethality was observed. The lowest dose of TSST1 tested which potentiated lethality was 10 ng/ml.
摘要
与中毒性休克综合征相关的金黄色葡萄球菌菌株会产生中毒性休克综合征毒素1（TSST1）。这种毒素具有多种生物学效应，包括在存在亚致死量脂多糖（LPS）的情况下增强兔子的致死率。由于鸡胚对LPS高度敏感，因此在该系统中研究了TSST1和LPS的协同作用。尽管TSST1本身对鸡胚没有影响，但它增强了LPS的致死作用。在每毫升存在高达10微克TSST1的情况下，LPS的50%致死剂量大大降低。然而，在高剂量的TSST1（大于100微克/毫升）时，未观察到致死率增强。测试的增强致死率的最低TSST1剂量为10纳克/毫升。
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