八个不同克隆的人白细胞干扰素cDNA的结构。

The structure of eight distinct cloned human leukocyte interferon cDNAs.

作者信息

Goeddel D V, Leung D W, Dull T J, Gross M, Lawn R M, McCandliss R, Seeburg P H, Ullrich A, Yelverton E, Gray P W

出版信息

Nature. 1981 Mar 5;290(5801):20-6. doi: 10.1038/290020a0.

Abstract

Eight classes of human leukocyte interferon (LeIFN) cDNA clones have been identified in a cDNA library prepared from a myeloblastoid cell line. The nucleotide sequences demonstrate that the multiple human LeIFN genes code for a family of homologous, yet distinct proteins. One of the cDNA clones may have been derived from the transcription of a LeIFN pseudogene.

摘要

在从一种成髓细胞样细胞系制备的cDNA文库中，已鉴定出八类人白细胞干扰素（LeIFN）cDNA克隆。核苷酸序列表明，多个人类LeIFN基因编码一族同源但又不同的蛋白质。其中一个cDNA克隆可能源自LeIFN假基因的转录。