Blaser M J, Black R E, Duncan D J, Amer J
J Clin Microbiol. 1985 Feb;21(2):164-7. doi: 10.1128/jcm.21.2.164-167.1985.
In Bangladesh and other developing countries, isolation of Campylobacter jejuni is common in healthy children, and the illness/infection ratio falls with age. To determine whether specific serum antibodies correlate with this phenomenon, using an enzyme-linked immunosorbent assay, we studied sera from 93 healthy Bangladeshi children and 121 healthy U.S. children under 15 years of age. For each age group (less than 1, 2 to 4, and 5 to 14 years) studied, specific serum antibody levels were significantly higher in the Bangladeshi children. Among Bangladeshi children, for each of the three immunoglobulin subclasses, the change in antibody levels with age was different. Specific immunoglobulin A antibody levels rose linearly with age, immunoglobulin G levels peaked in the 2- to 4-year age group and then fell, and immunoglobulin M levels peaked in the 2- to 4-year age group and then plateaued. Elevated serum antibody levels to C. jejuni in Bangladeshi children may be protective in themselves or may reflect other protective phenomena.
在孟加拉国和其他发展中国家，空肠弯曲菌在健康儿童中分离很常见，且疾病/感染比率随年龄下降。为了确定特定血清抗体是否与这种现象相关，我们使用酶联免疫吸附测定法，研究了93名15岁以下健康孟加拉国儿童和121名健康美国儿童的血清。对于所研究的每个年龄组（小于1岁、2至4岁以及5至14岁），孟加拉国儿童的特定血清抗体水平显著更高。在孟加拉国儿童中，对于三种免疫球蛋白亚类中的每一种，抗体水平随年龄的变化都不同。特异性免疫球蛋白A抗体水平随年龄呈线性上升，免疫球蛋白G水平在2至4岁年龄组达到峰值然后下降，免疫球蛋白M水平在2至4岁年龄组达到峰值然后趋于平稳。孟加拉国儿童中空肠弯曲菌血清抗体水平升高本身可能具有保护作用，或者可能反映其他保护现象。
