PURPOSE: This review summarizes the current use of extended reality (XR) including virtual reality (VR), mixed reality, and augmented reality (AR) in the medical field, ranging from medical imaging to training to preoperative planning. It covers the integration of these technologies into clinical practice and within medical training while discussing the challenges and future opportunities in this sphere. This will hopefully encourage more physicians to collaborate on integrating medicine and technology. APPROACH: The review was written by experts in the field based on their knowledge and on recent publications exploring the topic of extended realities in medicine. RESULTS: Based on our findings, XR including VR, mixed reality, and AR are increasingly utilized within surgery both for preoperative planning and intraoperative procedures. These technologies are also promising means for improved education at every level of physician training. However, there are still barriers to the widespread adoption of VR, mixed reality, and AR, including human factors, technological challenges, and regulatory issues. CONCLUSIONS: Based on the current use of VR, mixed reality, and AR, it is likely that the use of these technologies will continue to grow over the next decade. To support the development and integration of XR into medicine, it is important for academic groups to collaborate with industrial groups and regulatory agencies in these endeavors. These joint projects will help address the current limitations and mutually benefit both fields.