Detection of neurologic changes in critically ill infants using deep learning on video data: a retrospective single center cohort study.

BACKGROUND

Infant alertness and neurologic changes can reflect life-threatening pathology but are assessed by physical exam, which can be intermittent and subjective. Reliable, continuous methods are needed. We hypothesized that our computer vision method to track movement, pose artificial intelligence (AI), could predict neurologic changes in the neonatal intensive care unit (NICU).

METHODS

We collected video data linked to electroencephalograms (video-EEG) from infants with corrected age less than 1 year at Mount Sinai Hospital in New York City, a level four urban NICU between February 1, 2021 and December 31, 2022. We trained a deep learning pose recognition algorithm on video feeds, labeling 14 anatomic landmarks in 25 frames/infant. We then trained classifiers on anatomic landmarks to predict cerebral dysfunction, diagnosed from EEG readings by an epileptologist, and sedation, defined by the administration of sedative medications.

FINDINGS

We built the largest video-EEG dataset to date (282,301 video minutes, 115 infants) sampled from a diverse patient population. Infant pose was accurately predicted in cross-validation, held-out frames, and held-out infants with respective receiver operating characteristic area under the curves (ROC-AUCs) 0.94, 0.83, 0.89. Median movement increased with age and, after accounting for age, was lower with sedative medications and in infants with cerebral dysfunction (all P < 5 × 10, 10,000 permutations). Sedation prediction had high performance on cross-validation, held-out intervals, and held-out infants (ROC-AUCs 0.90, 0.91, 0.87), as did prediction of cerebral dysfunction (ROC-AUCs 0.91, 0.90, 0.76).

INTERPRETATION

We show that pose AI can be applied in an ICU setting and that an EEG diagnosis, cerebral dysfunction, can be predicted from video data alone. Deep learning with pose AI may offer a scalable, minimally invasive method for neuro-telemetry in the NICU.

FUNDING

Friedman Brain Institute Fascitelli Scholar Junior Faculty Grant and Thrasher Research Fund Early Career Award (F.R.). The Clinical and Translational Science Awards (CTSA) grant UL1TR004419 from the National Center for Advancing Translational Sciences. Office of Research Infrastructure of the National Institutes of Health under award number S10OD026880 and S10OD030463.