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接种各种人类肠道细菌的悉生小鼠肠道中艰难梭菌细胞毒素产生的调节

Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.

作者信息

Corthier G, Dubos F, Raibaud P

出版信息

Appl Environ Microbiol. 1985 Jan;49(1):250-2. doi: 10.1128/aem.49.1.250-252.1985.

DOI:10.1128/aem.49.1.250-252.1985
PMID:3977313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238383/
Abstract

Gnotobiotic mice died 2 days after inoculation of a cytotoxigenic Clostridium difficile strain. Protection occurred when mice were previously inoculated with a strain of Escherichia coli or Bifidobacterium bifidum. Intestinal cytotoxin production was highly reduced in the surviving mice, whereas the C. difficile population level did not decrease to a great extent.

摘要

无菌小鼠在接种产细胞毒素的艰难梭菌菌株后2天死亡。若小鼠预先接种大肠杆菌或双歧双歧杆菌菌株，则可获得保护。存活小鼠的肠道细胞毒素产生大幅减少，而艰难梭菌的菌量水平并未大幅下降。

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Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.接种各种人类肠道细菌的悉生小鼠肠道中艰难梭菌细胞毒素产生的调节
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本文引用的文献

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