与人类血清白蛋白结合的（ZZ）-胆红素IXα光化学变化的动力学研究。证明（EZ）-胆红素IXα是（ZZ）-胆红素IXα向（EZ）-环胆红素IXα光化学变化过程中的中间体。
Kinetic study of the photochemical changes of (ZZ)-bilirubin IX alpha bound to human serum albumin. Demonstration of (EZ)-bilirubin IX alpha as an intermediate in photochemical changes from (ZZ)-bilirubin IX alpha to (EZ)-cyclobilirubin IX alpha.
作者信息
Itoh S, Onishi S
出版信息
Biochem J. 1985 Feb 15;226(1):251-8. doi: 10.1042/bj2260251.
Abstract
The present study was performed to elucidate why the photochemical reaction of (ZZ)-bilirubin bound to human serum albumin is singularly selective, and only one of the two (EZ)- and (ZE)-bilirubins, the (ZE)-isomer, is produced. In a kinetic study of the photochemical reaction in vitro, the sum of the relative rate constants of photochemical transformation of (EZ)-bilirubin into both (EZ)-cyclobilirubin and (ZZ)-bilirubin, with a significant preference for the former, was proved to be considerably larger than that of the transformation of (ZZ)-bilirubin into (EZ)-bilirubin. Therefore only one of the geometrical isomers, namely (ZE)-bilirubin, is apparently formed. It was concluded that (EZ)-bilirubin photochemically undergoes (EZ)-cyclization, i.e. structural photoisomerization, while bound to its high-affinity site on human serum albumin, and is an intermediate in the transformation of (ZZ)-bilirubin into (EZ)-cyclobilirubin.
摘要
进行本研究是为了阐明与人类血清白蛋白结合的（ZZ）-胆红素的光化学反应为何具有独特的选择性，并且在两种（EZ）-和（ZE）-胆红素中，仅产生（ZE）-异构体这一种。在体外光化学反应的动力学研究中，已证明（EZ）-胆红素光化学转化为（EZ）-环胆红素和（ZZ）-胆红素（前者明显占优）的相对速率常数之和，远大于（ZZ）-胆红素转化为（EZ）-胆红素的速率常数之和。因此，显然仅形成一种几何异构体，即（ZE）-胆红素。得出的结论是，（EZ）-胆红素在与人血清白蛋白上的高亲和力位点结合时，会发生光化学（EZ）-环化，即结构光异构化，并且是（ZZ）-胆红素转化为（EZ）-环胆红素过程中的中间体。
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