胆红素IXα及其光产物的光化学和热转化动力学研究
Kinetic study of photochemical and thermal conversion of bilirubin IX alpha and its photoproducts.
作者信息
Isobe K, Itoh S, Onishi S, Yamakawa T, Ogino T, Yokoyama T
出版信息
Biochem J. 1983 Mar 1;209(3):695-700. doi: 10.1042/bj2090695.
Abstract
A kinetic study of the photochemical and thermal conversion of photoisomers, especialy peaks 0 and 3 [(EE)-bilirubin IX alpha and (EZ)- and (ZE)-bilirubin IX alpha], under anaerobic conditions, was performed by using reversed-phase high-pressure liquid chromatography. Peaks 0 and 3 are spontaneously, photochemically and thermally converted. Short-term photoirradiation of bilirubin gives a mixture containing not only the geometric isomers (EE)-, (EZ)- and (ZE)-bilirubin IX alpha, but also peak 2, (EZ)-cyclobilirubin IX alpha. On prolonged irradiation, cyclization and 15Z leads to 15E isomerization lead to gradual accumulation of two pairs of photoproducts: (EZ)-cyclobilirubin IX alpha A and B and (EE)-cyclobilirubin IX alpha A and B.
摘要
在厌氧条件下，利用反相高压液相色谱法对光异构体，特别是峰0和峰3[（EE）-胆红素IXα以及（EZ）-和（ZE）-胆红素IXα]的光化学和热转化进行了动力学研究。峰0和峰3会自发地、通过光化学和热进行转化。胆红素的短期光照射会产生一种混合物，其中不仅包含几何异构体（EE）-、（EZ）-和（ZE）-胆红素IXα，还包含峰2，即（EZ）-环胆红素IXα。长时间照射时，环化以及15Z向15E的异构化会导致两对光产物逐渐积累：（EZ）-环胆红素IXα A和B以及（EE）-环胆红素IXα A和B。
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本文引用的文献
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Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.一名高胆红素血症新生儿血清中胆红素-IXα几何异构体的证实及黄疸光疗机制
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High-pressure liquid chromatographic analysis of anaerobic photoproducts of bilirubin-IX alpha in vitro and its comparison with photoproducts in vivo.胆红素-IXα体外厌氧光产物的高压液相色谱分析及其与体内光产物的比较。
Biochem J. 1980 Sep 15;190(3):527-32. doi: 10.1042/bj1900527.
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