Zhou Tianjing, Wu Jianming, Wang Yingwei, Gao Yu, Cheng Kai
Department of Dermatology, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jan 4;18:7-18. doi: 10.2147/CCID.S497128. eCollection 2025.
Psoriasis is associated with obesity, which in turn is linked to increased mortality risk. Therefore, we undertook a cohort study utilizing data from the National Health and Nutrition Examination Survey (NHANES) to examine the impact of weight-adjusted waist index (WWI) on the likelihood of all-cause mortality in psoriasis individuals.
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) to investigate the influence of WWI on the probability of all-cause mortality in psoriasis individuals. A retrospective cohort analysis included 19,919 participants aged 18 to 80 years, with or without psoriasis. The primary endpoint studied was all-encompassing mortality up to December 2019. The interplay between WWI and psoriasis was analyzed through multivariable logistic regression techniques. Survival probabilities were assessed employing Kaplan-Meier curves and Cox regression analyses.
Out of the 19,919 subjects that we eventually included, 522 had psoriasis. Psoriasis and WWI were found to be significantly positively correlated. A significant correlation was found between an incremental unit increase in WWI and a 63% increased risk of all-cause mortality risk in psoriasis patients (HR = 1.63, 95% CI 1.02-2.61). Subgroup analyses demonstrated consistent findings within the psoriasis population. These findings suggest an independent impact of WWI on psoriasis risk and mortality.
Our investigation revealed that there is a strong positive correlation between WWI and all-cause mortality in US psoriasis adults. For those with psoriasis, managing WWI, or obesity, is crucial.
银屑病与肥胖相关，而肥胖又与死亡风险增加有关。因此，我们利用来自美国国家健康与营养检查调查（NHANES）的数据进行了一项队列研究，以检验体重调整腰围指数（WWI）对银屑病患者全因死亡可能性的影响。
本研究利用美国国家健康与营养检查调查（NHANES）的数据，调查WWI对银屑病患者全因死亡概率的影响。一项回顾性队列分析纳入了19919名年龄在18至80岁之间、有或无银屑病的参与者。研究的主要终点是截至2019年12月的全因死亡率。通过多变量逻辑回归技术分析WWI与银屑病之间的相互作用。采用Kaplan-Meier曲线和Cox回归分析评估生存概率。
在我们最终纳入的19919名受试者中，522人患有银屑病。发现银屑病与WWI显著正相关。发现WWI每增加一个单位，银屑病患者的全因死亡风险就增加63%（风险比=1.63，95%置信区间1.02-2.61）。亚组分析在银屑病人群中显示了一致的结果。这些发现表明WWI对银屑病风险和死亡率有独立影响。
我们的调查显示，在美国成年银屑病患者中，WWI与全因死亡率之间存在很强的正相关。对于银屑病患者来说，控制WWI或肥胖至关重要。
