Schiano Elisabetta, Piccolo Vincenzo, Novellino Ettore, Maisto Maria, Iannuzzo Fortuna, Summa Vincenzo, Tenore Gian Carlo
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy.
Department of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Foods. 2022 Mar 30;11(7):1010. doi: 10.3390/foods11071010.
Due to the side effects of synthetic drugs, the interest in the beneficial role of natural products in the management of diabetic conditions is growing over time. In the context of agro-food waste products, a screening of different fruit thinning by-products identified thinned nectarines (TN) as the richest matrices of abscisic acid (ABA), a phytohormone with well-documented hypoglycemic potential. These waste-food matrices may represent not only precious sources of ABA but also other bioactive molecules with potential health benefits, such as polyphenols. Therefore, we aimed to perform a qualitative and quantitative characterization of a polyphenolic profile of a TN-based nutraceutical formulation through HPLC-HESI-MS/MS and HPLC-DAD-FLD analyses. Additionally, the in vitro antioxidant and antidiabetic potential of TN was investigated. HPLC analyses allowed us to identify forty-eight polyphenolic compounds, nineteen of which were quantified. Moreover, the results obtained through different in vitro assays showed the antioxidant and antidiabetic potential exerted by the tested nutraceutical formulation. In conclusion, the concomitant presence of different bioactive compounds in TN-based nutraceutical formulation, such as ABA and polyphenols, would reasonably support TN as an innovative nutraceutical formulation useful for the management of glucose homeostasis. Further in-depth animal-based studies and clinical trials are needed to deepen these aspects.
由于合成药物的副作用，人们对天然产物在糖尿病治疗中的有益作用的兴趣与日俱增。在农业食品废弃物的背景下，对不同水果疏果副产物的筛选确定了疏果油桃（TN）是脱落酸（ABA）含量最丰富的基质，脱落酸是一种具有充分记录的降血糖潜力的植物激素。这些废弃食品基质不仅可能是ABA的宝贵来源，还可能是其他具有潜在健康益处的生物活性分子，如多酚。因此，我们旨在通过HPLC-HESI-MS/MS和HPLC-DAD-FLD分析对基于TN的营养制剂的多酚谱进行定性和定量表征。此外，还研究了TN的体外抗氧化和抗糖尿病潜力。HPLC分析使我们能够鉴定出48种多酚化合物，其中19种进行了定量分析。此外，通过不同体外试验获得的结果表明了受试营养制剂具有抗氧化和抗糖尿病潜力。总之，基于TN的营养制剂中同时存在不同的生物活性化合物，如ABA和多酚，将合理地支持TN作为一种用于管理葡萄糖稳态的创新营养制剂。需要进一步深入的动物研究和临床试验来深化这些方面。
