Saratto Timo, Visuri Kerkko, Lehtinen Jonatan, Ortega-Sanz Irene, Steenwyk Jacob L, Sihvonen Samuel
Solu Healthcare Oy, Kalevankatu 31 A 13, 00100, Helsinki, Finland.
Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
BMC Bioinformatics. 2025 Jan 13;26(1):12. doi: 10.1186/s12859-024-06005-z.
Genomic surveillance is extensively used for tracking public health outbreaks and healthcare-associated pathogens. Despite advancements in bioinformatics pipelines, there are still significant challenges in terms of infrastructure, expertise, and security when it comes to continuous surveillance. The existing pipelines often require the user to set up and manage their own infrastructure and are not designed for continuous surveillance that demands integration of new and regularly generated sequencing data with previous analyses. Additionally, academic projects often do not meet the privacy requirements of healthcare providers.
We present Solu, a cloud-based platform that integrates genomic data into a real-time, privacy-focused surveillance system.
Solu's accuracy for taxonomy assignment, antimicrobial resistance genes, and phylogenetics was comparable to established pathogen surveillance pipelines. In some cases, Solu identified antimicrobial resistance genes that were previously undetected. Together, these findings demonstrate the efficacy of our platform.
By enabling reliable, user-friendly, and privacy-focused genomic surveillance, Solu has the potential to bridge the gap between cutting-edge research and practical, widespread application in healthcare settings. The platform is available for free academic use at https://platform.solugenomics.com .
基因组监测广泛用于追踪公共卫生疫情和医疗相关病原体。尽管生物信息学流程取得了进展，但在持续监测方面，在基础设施、专业知识和安全性方面仍存在重大挑战。现有的流程通常要求用户建立和管理自己的基础设施，并且不是为需要将新的和定期生成的测序数据与先前分析相结合的持续监测而设计的。此外，学术项目往往不符合医疗服务提供者的隐私要求。
我们推出了Solu，这是一个基于云的平台，可将基因组数据集成到一个实时、注重隐私的监测系统中。
Solu在分类学分配、抗菌药物耐药基因和系统发育方面的准确性与既定的病原体监测流程相当。在某些情况下，Solu识别出了以前未检测到的抗菌药物耐药基因。这些发现共同证明了我们平台的有效性。
通过实现可靠、用户友好且注重隐私的基因组监测，Solu有潜力弥合前沿研究与医疗环境中实际广泛应用之间的差距。该平台可在https://platform.solugenomics.com免费供学术使用。
