Li Nan, Qiao Enfa, Duan Zhaojun, Li Lili, Jiang Lili, Cun Jianping, Zhou Xiaofang, Wang Zhi Chao, Zhou Yongming, Cao Yihui
Yunnan Provincial Key Laboratory of Public Health and Biosafety & Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, China.
National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Front Pediatr. 2025 Jan 8;12:1497467. doi: 10.3389/fped.2024.1497467. eCollection 2024.
Rotavirus (RV), norovirus (NoV), human enteric adenovirus (HAdV), human astrovirus (HAstV), and sapovirus (SaV) are important viral causes of acute gastroenteritis (AGE) in children. However, limited information is available regarding AGE in Yunnan, Southwest China.
To investigate the prevalence of group A rotavirus (RVA), norovirus genogroups I (GI) and II (GII), and HAdV, HAstV, and SaV in children aged <5 years hospitalized with AGE between 2020 and 2022.
Stool samples were collected from 612 children hospitalized with AGE. A total of 266 of the 612 children presented with AGE (43.46%; 266/612). RVA was detected in 28.76% (176 of 612) of the children. Rotavirus G9P[8] was the most frequent genotype in 2020 and 2021. In 2022, G8P[8] became the dominant genotype combination circulating in Yunnan Province. The norovirus positivity rate was present in 11.93% (73/612) of the 612 samples. Of the 45 GII successfully sequenced samples, GII.4 was the dominant genotype, accounting for 51.11% (23 of 45), followed by GII.3 [P12] (28.89%; 13 of 45). The positivity rates for SaV, HAstV, and HAdV were 2.94% (18/612), 3.43% (21/612), and 4.74% (29/612), respectively. HAdV-F41 was the predominant genotype and non-enteric HAdV-C2 and HAdV-A12 were also observed in Yunnan. Male children had a higher incidence of AGE than female children upon infection with RV, NoV, and HAdV. The highest incidence of AGE was observed among children aged between 12 and 23 months (62.50%; 120/192), followed by children aged between 24 and 35 months (52.44%; 43/82). The incidence rate of the infection peaked (78.62%; 125/159) in the first 3 months of the year, followed by the next 3 months (66.67%; 70/105).
RV and NoV remained the most important agents causing AGE. RV G8P[8] became the dominant circulating genotype instead of G9P[8] in Yunnan in 2022. The authors suggest that monitoring should be strengthened to prevent outbreaks caused by RV G8P[8]. New vaccines, such as the RV G8P[8] genotype, should be considered.
轮状病毒（RV）、诺如病毒（NoV）、人肠道腺病毒（HAdV）、人星状病毒（HAstV）和札如病毒（SaV）是儿童急性胃肠炎（AGE）的重要病毒病因。然而，关于中国西南部云南省急性胃肠炎的信息有限。
调查2020年至2022年间因急性胃肠炎住院的5岁以下儿童中A组轮状病毒（RVA）、诺如病毒基因群I（GI）和II（GII）以及HAdV、HAstV和SaV的流行情况。
收集了612例因急性胃肠炎住院儿童的粪便样本。612例儿童中共有266例出现急性胃肠炎（43.46%；266/612）。在28.76%（612例中的176例）的儿童中检测到RVA。轮状病毒G9P[8]是2020年和2021年最常见的基因型。2022年，G8P[8]成为云南省流行的主要基因型组合。612份样本中诺如病毒阳性率为11.93%（73/612）。在45份成功测序的GII样本中，GII.4是主要基因型，占51.11%（45例中的23例），其次是GII.3 [P12]（28.89%；45例中的13例）。SaV、HAstV和HAdV的阳性率分别为2.94%（18/612）、3.43%（21/612）和4.74%（29/612）。HAdV-F41是主要基因型，在云南还观察到非肠道型HAdV-C2和HAdV-A12。感染RV、NoV和HAdV时，男童急性胃肠炎的发病率高于女童。急性胃肠炎发病率最高的是12至23个月龄的儿童（62.50%；120/192），其次是24至35个月龄的儿童（52.44%；43/82）。感染发病率在一年的前3个月达到峰值（78.62%；125/159），其次是接下来的3个月（66.67%；70/105）。
RV和NoV仍然是导致急性胃肠炎的最重要病原体。2022年在云南，RV G8P[8]取代G9P[8]成为主要流行基因型。作者建议应加强监测以预防由RV G8P[8]引起的疫情爆发。应考虑研发新疫苗，如RV G8P[8]基因型疫苗。
