Le Grill Sylvain, Brouillet Fabien, Drouet Christophe
CIRIMAT, Toulouse INP, Université Toulouse 3 Paul Sabatier, CNRS, Université de Toulouse, 4 Allée Emile Monso, BP44362, CEDEX 4, 31030 Toulouse, France.
Regenerative Nanomedicine Unit, Center of Research on Biomedicines of Strasbourg (CRBS), French National Institute of Health and Medical Research (INSERM), University of Strasbourg, UMR 1260, 1 Rue Eugène Boeckel, 67000 Strasbourg, France.
Bioengineering (Basel). 2025 Jan 7;12(1):38. doi: 10.3390/bioengineering12010038.
Bone is a natural mineral-organic nanocomposite protecting internal organs and allowing mobility. Through the ages, numerous strategies have been developed for repairing bone defects and fixing fractures. Several generations of bone repair biomaterials have been proposed, either based on metals, ceramics, glasses, or polymers, depending on the clinical need, the maturity of technologies, and knowledge of the natural constitution of the bone tissue to be repaired. The global trend in bone implant research is shifting toward osteointegrative, bioactive and possibly stimuli-responsive biomaterials and, where possible, resorbable implants that actively promote the regeneration of natural bone tissue. In this mini-review, the fundamentals of bone healing materials and clinical challenges are summarized and commented on with regard to progressing scientific discoveries. The main types of bone-healing materials are then reviewed, and their specific relevance to the field is reminded, with the citation of reference works. In the final part, we highlight the promise of hybrid organic-inorganic bioactive materials and the ongoing research activities toward the development of multifunctional or stimuli-responsive implants. This contribution is expected to serve as a commented introduction to the ever-progressing field of bone regeneration and highlight trends of future-oriented research.
骨骼是一种天然的矿物-有机纳米复合材料，可保护内部器官并实现机体活动。长期以来，人们开发了多种修复骨缺损和固定骨折的方法。根据临床需求、技术成熟度以及待修复骨组织的自然组成知识，已经提出了几代骨修复生物材料，包括基于金属、陶瓷、玻璃或聚合物的材料。骨植入物研究的全球趋势正朝着骨整合、生物活性且可能具有刺激响应性的生物材料发展，并且在可能的情况下，朝着能够积极促进天然骨组织再生的可吸收植入物发展。在这篇小型综述中，我们总结并评论了骨愈合材料的基本原理以及与科学发现进展相关的临床挑战。然后回顾了主要类型的骨愈合材料，并引用参考文献提醒它们与该领域的具体相关性。在最后一部分，我们强调了有机-无机杂化生物活性材料的前景以及正在进行的多功能或刺激响应性植入物开发的研究活动。这篇文章旨在对不断发展的骨再生领域进行有评论的介绍，并突出未来导向研究的趋势。
