Lee Jeongmin, Hong Seok Min, Choi Yong Sung, Lee Jinseok, Yeo Joon Hyung, Kim Sung Soo, Lee Jae Min, Yon Dong Keon, Yeo Seung Geun
Department of Medicine, College of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of Korea.
Antioxidants (Basel). 2024 Dec 24;14(1):3. doi: 10.3390/antiox14010003.
Many studies have evaluated the roles of free radicals and reactive oxygen species (ROS) in various diseases. To date, however, no systematic review has specifically investigated the involvement of free radicals and ROS in acute otitis media (OM), OM with effusion, and chronic OM. The present study therefore assessed the roles of free radicals and ROS in OM. SCOPUS, PubMed, Cochrane Library, EMBASE, and Google Scholar were comprehensively searched to identify studies assessing the roles of free radicals and ROS in OM. Relevant studies were identified and their findings summarized. The literature search identified 21 studies. A review of their findings showed that the concentrations of hydrogen peroxide (HO), lipid hydroperoxide (LPO), and myeloperoxidase (MPO) were elevated in patients with acute OM; that the concentrations of HO, LPO, MPO, xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MDA), hydroxyl radical (·OH), and nitrotyrosine were elevated in patients with OM with effusion; and that the levels of nitric oxide (NO), MPO, 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) were elevated in patients with chronic OM. Although some studies reported that SOD levels were increased in patients with OM with effusion, decreases in antioxidants such as SOD and catalase, as well as total antioxidant capacity, were observed across all types of OM. Although the levels of free radicals and ROS varied by type of OM, study design, control group selection, sample type, ROS and free radical markers, and antioxidant types, most studies showed increased ROS and decreased antioxidants in OM patients. These findings suggest that levels of free radicals and ROS are strongly associated with the pathophysiology of OM.
许多研究评估了自由基和活性氧（ROS）在各种疾病中的作用。然而，迄今为止，尚无系统综述专门研究自由基和ROS在急性中耳炎（OM）、分泌性中耳炎和慢性中耳炎中的作用。因此，本研究评估了自由基和ROS在中耳炎中的作用。全面检索了SCOPUS、PubMed、Cochrane图书馆、EMBASE和谷歌学术，以确定评估自由基和ROS在中耳炎中作用的研究。识别出相关研究并总结其结果。文献检索共识别出21项研究。对其结果的综述表明，急性中耳炎患者的过氧化氢（HO）、脂质过氧化氢（LPO）和髓过氧化物酶（MPO）浓度升高；分泌性中耳炎患者的HO、LPO、MPO、黄嘌呤氧化酶（XO）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、丙二醛（MDA）、羟基自由基（·OH）和硝基酪氨酸浓度升高；慢性中耳炎患者的一氧化氮（NO）、MPO、4-羟基壬烯醛（4-HNE）和丙二醛（MDA）水平升高。尽管一些研究报告分泌性中耳炎患者的SOD水平升高，但在所有类型的中耳炎中均观察到SOD和过氧化氢酶等抗氧化剂以及总抗氧化能力下降。尽管自由基和ROS的水平因中耳炎类型、研究设计、对照组选择、样本类型、ROS和自由基标志物以及抗氧化剂类型而异，但大多数研究表明中耳炎患者的ROS升高而抗氧化剂下降。这些发现表明，自由基和ROS的水平与中耳炎的病理生理学密切相关。
