Koppayithodi Sudeep, Singh Nishant
Institute of Advanced Materials (INAM), Universitat Jaume I, Castelló de la Plana 12071, Spain.
J Am Chem Soc. 2025 Feb 12;147(6):5293-5299. doi: 10.1021/jacs.4c16416. Epub 2025 Jan 28.
Phase-separated coacervates can enhance reaction kinetics and guide multilevel self-assembly, mimicking early cellular evolution. In this work, we introduce "reactive" complex coacervates that undergo chemically triggered self-immolative transformations, directing the self-assembly of the reaction products within their matrix. These self-assemblies then evolve to show life-like properties such as budding and membrane formation. We find that the coacervate composition critically influences reaction rates and product distribution and guides the hierarchical self-assembly. This work showcases "reactive" coacervates as a versatile platform to influence reaction and self-assembly pathways for controlled supramolecular synthesis and hierarchical self-organization in confined spaces.
相分离凝聚层可以增强反应动力学并引导多级自组装，模拟早期细胞进化。在这项工作中，我们引入了“反应性”复合凝聚层，其经历化学触发的自牺牲转变，在其基质内引导反应产物的自组装。然后这些自组装体进化以展现出诸如出芽和膜形成等类似生命的特性。我们发现凝聚层的组成对反应速率和产物分布有至关重要的影响，并引导分级自组装。这项工作展示了“反应性”凝聚层作为一个通用平台，可用于影响反应和自组装途径，以在受限空间中进行可控的超分子合成和分级自组织。
