Agnew Megan, Cadmus-Bertram Lisa, Kwekkeboom Kristine, Trentham-Dietz Amy, Gangnon Ronald, Schmidt Christian, Andersen Shaneda Warren
Department of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin Madison, 1685 Highland Ave, MFCB, Madison, WI, 53705, USA.
Department of Kinesiology, University of Wisconsin Madison, 1300 University Ave, Madison, WI, 53706, USA.
Support Care Cancer. 2025 Jan 30;33(2):131. doi: 10.1007/s00520-025-09196-0.
Physical activity (PA) is associated with better quality of life for cancer survivors; however, less is known about this association among individuals with advanced cancer. This study assesses whether changes in PA following an advanced cancer diagnosis are associated with health-related quality of life (HRQoL) outcomes.
Data were collected from 247 participants in a survey of adults with advanced cancer who visited the University of Wisconsin Carbone Cancer Center (January 2021-2023). PA since cancer diagnosis was assessed using a validated, self-reported tool. HRQoL was assessed using the Functional Assessment of Cancer Therapy - General and Patient-Reported Outcomes Measurement Information System measures of physical function, fatigue, and pain interference. We used generalized linear models to assess relationships between PA and HRQoL.
Most adults with advanced cancer were insufficiently active (53%), and reported a lot less activity (41%) after diagnosis, followed by a little less activity (33%), and the same/more activity (26%). Compared to the other activity groups, those who reported a lot less activity had the worst HRQoL scores, including lower HRQoL (x̄ = 70.3 vs. x̄ = 82.6, 90.7) and physical function (x̄ = 40.3 vs. x̄ = 47.3, 52.5), and higher fatigue (x̄ = 59.3 vs. x̄ = 51.4, 42.3) and pain interference (x̄ = 55.5 vs. x̄ = 48.8, 45.6).
Adults with advanced cancer who report PA reductions have worse HRQoL, higher pain and fatigue, and lower physical function than those engaging in the same/more PA since their diagnosis. Future interventions focused on improving HRQoL among adults with advanced cancer should incorporate light-intensity PA to reduce declines following diagnosis.
身体活动（PA）与癌症幸存者更好的生活质量相关；然而，对于晚期癌症患者中这种关联的了解较少。本研究评估晚期癌症诊断后PA的变化是否与健康相关生活质量（HRQoL）结果相关。
对247名访问威斯康星大学卡本癌症中心的晚期癌症成年患者进行调查（2021年1月至2023年），收集数据。自癌症诊断以来的PA使用经过验证的自我报告工具进行评估。HRQoL使用癌症治疗功能评估 - 通用版以及患者报告结果测量信息系统中身体功能、疲劳和疼痛干扰的测量指标进行评估。我们使用广义线性模型来评估PA与HRQoL之间的关系。
大多数晚期癌症成年患者活动不足（53%），且诊断后报告活动量大幅减少的患者占41%，其次是活动量略有减少的患者（33%），以及活动量相同/增加的患者（26%）。与其他活动组相比，报告活动量大幅减少的患者HRQoL得分最差，包括较低的HRQoL（平均值 = 70.3 vs. 平均值 = 82.6, 90.7）和身体功能（平均值 = 40.3 vs. 平均值 = 47.3, 52.5），以及较高的疲劳（平均值 = 59.3 vs. 平均值 = 51.4, 42.3）和疼痛干扰（平均值 = 55.5 vs. 平均值 = 48.8, 45.6）。
与诊断后保持相同/更多PA的晚期癌症成年患者相比，报告PA减少的患者HRQoL更差，疼痛和疲劳程度更高，身体功能更低。未来针对改善晚期癌症成年患者HRQoL的干预措施应纳入低强度PA，以减少诊断后的下降。
