Aminnezhad Sargol, Hama Nabaz Hamarashid, Hasan Ayad H, Bagheri Fatemeh, Alavi Mehran
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
Medical Laboratory Science Department, College of Science, Komar University of Science and Technology, Sulaimani, Kurdistan Region, Iraq.
Int J Biol Macromol. 2025 Apr;301:140331. doi: 10.1016/j.ijbiomac.2025.140331. Epub 2025 Jan 31.
Printed form of polymeric nanomaterials in formation, crosslinking, structure, properties, toxicity and biocompatibility refers to the application of nanotechnology and 3D printing techniques to fabricate polymeric nanomaterials with specific physicochemical and biomedical features. In this regard, applications of 3D printing techniques, specifically for production of 3D scaffold have received huge attention in diabetes and bacterial infections. This review has tried to address recent advances and challenges related to applications of biocompatible polymeric nanomaterials in 3D printing techniques to ameliorate bacterial infections and diabetes. The applications of metal/metal oxide such as silver, gold, zinc, and titanium dioxide, and polymeric nanoparticles can augment the antimicrobial and degradation characteristics of 3D-printed scaffolds. The rapid advancements in 3D bio-printed scaffolds, specifically by artificial intelligence (AI) present a transformative landscape for diabetes treatment, addressing the complex challenges associated with impaired wound healing and tissue regeneration in individuals with diabetes mellitus.
聚合物纳米材料在形成、交联、结构、性质、毒性和生物相容性方面的印刷形式是指应用纳米技术和3D打印技术来制造具有特定物理化学和生物医学特性的聚合物纳米材料。在这方面，3D打印技术的应用，特别是用于生产3D支架，在糖尿病和细菌感染方面受到了极大关注。本综述试图探讨生物相容性聚合物纳米材料在3D打印技术中的应用，以改善细菌感染和糖尿病的最新进展和挑战。金属/金属氧化物如银、金、锌和二氧化钛以及聚合物纳米颗粒的应用可以增强3D打印支架的抗菌和降解特性。3D生物打印支架的快速发展，特别是通过人工智能（AI），为糖尿病治疗呈现了一个变革性的前景，解决了糖尿病患者伤口愈合受损和组织再生相关的复杂挑战。
