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[In vitro activity of oral cephalosporins (author's transl)].

作者信息

Wiedemann B, Flensberg T

出版信息

Infection. 1979;7 Suppl 6:551-3. doi: 10.1007/BF01659733.

DOI:10.1007/BF01659733
PMID:399247
Abstract

The in vitro activity of cephradine, cephalexin, and cefaclor was studied in comparison with that of cephalothin. Cefaclor inhibits peptidoglycan synthesis somewhat more than cephalexin and cephradine. There is no marked difference in the stability of the three substances in the presence of beta-lactamases, and the outer membrane of Escherichia coli is no barrier to permeation of any of the three antibiotics.

摘要

相似文献

1
[In vitro activity of oral cephalosporins (author's transl)].
Infection. 1979;7 Suppl 6:551-3. doi: 10.1007/BF01659733.
2
[In vitro activity of cefaclor (author's transl)].头孢克洛的体外活性（作者译）
Infection. 1979;7 Suppl 6:518-26. doi: 10.1007/BF01659726.
3
Cefaclor and cefatrizine, new investigational orally administered cephalosporins. In-vitro collaborative evaluation against clinical bacterial isolates and comparison with related antimicrobics.
Am J Clin Pathol. 1979 Oct;72(4):578-85. doi: 10.1093/ajcp/72.4.578.
4
Comparison of in vitro antibacterial activity of three oral cephalosporins: cefaclor, cephalexin, and cephradine.三种口服头孢菌素（头孢克洛、头孢氨苄和头孢拉定）的体外抗菌活性比较
Antimicrob Agents Chemother. 1977 Nov;12(5):591-6. doi: 10.1128/AAC.12.5.591.
5
The in vitro spectrum of the cephalosporins.头孢菌素的体外抗菌谱。
Mayo Clin Proc. 1976 Apr;51(4):237-50.
6
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.头孢氨苄、头孢拉定和头孢克洛的体外活性比较。
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
7
A comparison of the activity in vitro of different cephalosporins: cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime and cefotaxime.不同头孢菌素的体外活性比较：头孢噻吩、头孢拉定、头孢乙腈、头孢克洛、头孢呋辛和头孢噻肟。
Boll Ist Sieroter Milan. 1980 Jan 31;58(6):488-95.
8
In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin.
J Antibiot (Tokyo). 1977 Sep;30(9):753-5. doi: 10.7164/antibiotics.30.753.
9
A pharmacological and in vitro comparison of three oral cephalosporins.
J Antimicrob Chemother. 1979 Sep;5(5):601-7. doi: 10.1093/jac/5.5.601.
10
Summary of laboratory studies on the antibacterial activity of cefaclor.头孢克洛抗菌活性的实验室研究总结。
Postgrad Med J. 1979;55 Suppl 4:22-9.

本文引用的文献

1
The beta-lactamases of gram-negative bacteria and their possible physiological role.革兰氏阴性菌的β-内酰胺酶及其可能的生理作用。
Adv Microb Physiol. 1973;9:31-88. doi: 10.1016/s0065-2911(08)60376-8.
2
Comparison of in vitro antibacterial activity of three oral cephalosporins: cefaclor, cephalexin, and cephradine.三种口服头孢菌素（头孢克洛、头孢氨苄和头孢拉定）的体外抗菌活性比较
Antimicrob Agents Chemother. 1977 Nov;12(5):591-6. doi: 10.1128/AAC.12.5.591.
3
Comparative study of seven cephalosporins: susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coli.
七种头孢菌素的比较研究：对β-内酰胺酶的敏感性及穿透大肠杆菌表层的能力
Antimicrob Agents Chemother. 1976 Aug;10(2):219-22. doi: 10.1128/AAC.10.2.219.
4
Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.评估β-内酰胺酶不敏感青霉素和头孢菌素在大肠杆菌菌株中渗透性的间接方法。
Antimicrob Agents Chemother. 1976 Aug;10(2):215-8. doi: 10.1128/AAC.10.2.215.
5
Cefaclor: in vitro spectrum of activity and beta-lactamase stability.头孢克洛：体外活性谱及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. doi: 10.1128/AAC.13.4.584.
6
Penetration through the gram-negative cell wall: a co-determinant of the efficacy of beta-lactam antibiotics.穿透革兰氏阴性菌细胞壁：β-内酰胺类抗生素疗效的共同决定因素
Int J Clin Pharmacol Biopharm. 1979 Mar;17(3):131-4.