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用于磁热疗癌症治疗的共沉淀钴铁氧体纳米粒子的多方面表征与治疗评估

Multifaceted Characterization and Therapeutic Evaluation of Co-precipitated Cobalt Ferrite Nanoparticles for Magnetic Hyperthermia Cancer Therapy.

作者信息

Reena R Jafrin, Raj N Arunai Nambi

机构信息

Department of Physics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

出版信息

J Med Phys. 2024 Oct-Dec;49(4):510-518. doi: 10.4103/jmp.jmp_57_24. Epub 2024 Dec 18.

DOI:10.4103/jmp.jmp_57_24
PMID:39926154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11801102/
Abstract

AIM

Magnetic-mediated hyperthermia has emerged as a promising therapeutic approach for treating cancer. This technique employs the heat dissipated by the magnetic nanoparticles when subjected to an external varying magnetic field, to bring about localized hyperthermia in tumor tissues. Owing to their conducive and tuneable "physical, chemical, and magnetic" characteristics, cobalt ferrite (CoFeO) nanoparticles are recognized as emerging contenders. The aim of the present work was to enhance the magnetic characteristics and guarantee the efficacy of CoFe2 O4 nanoparticles in targeting and eliminating cancer cells.

METHODS

CoFeO nanoparticles were synthesized using the chemical co-precipitation route and underwent rigorous structural, morphological, and magnetic characterization techniques. The synthesized particles were then subjected to studies to evaluate their cytotoxicity and antimicrobial susceptibility.

RESULTS

The characterization techniques confirmed the cubic structure, ferrite phase, and spherical and magnetic nature of CoFeO nanoparticles. The zeta potential was found to be - 0.0048V (4.8 mV). Cytotoxicity analysis exhibited decreased cell viability with increasing concentrations of CoFeO nanoparticles. Antimicrobial studies displayed good inhibiting properties.

CONCLUSION

The zeta potential of the synthesized CoFeO nanoparticles was found to be higher than that of the breast cancer cells (MCF-7) which proves the synthesized drug to be effective. The studies also disclose the efficacy of the drug over cancer cells.

摘要

目的

磁介导热疗已成为一种很有前景的癌症治疗方法。该技术利用磁性纳米颗粒在外部变化磁场作用下产生的热量，在肿瘤组织中实现局部热疗。由于具有良好的且可调节的“物理、化学和磁性”特性，钴铁氧体（CoFeO）纳米颗粒被认为是新兴的有力竞争者。本研究的目的是增强CoFe2O4纳米颗粒的磁性特性，并确保其在靶向和消除癌细胞方面的有效性。

方法

采用化学共沉淀法合成CoFeO纳米颗粒，并对其进行严格的结构、形态和磁性表征技术研究。然后对合成的颗粒进行研究，以评估其细胞毒性和抗菌敏感性。

结果

表征技术证实了CoFeO纳米颗粒的立方结构、铁氧体相以及球形和磁性性质。发现zeta电位为-0.0048V（4.8mV）。细胞毒性分析表明，随着CoFeO纳米颗粒浓度的增加，细胞活力降低。抗菌研究显示出良好的抑制性能。

结论

发现合成的CoFeO纳米颗粒的zeta电位高于乳腺癌细胞（MCF-7）的zeta电位，这证明合成药物是有效的。研究还揭示了该药物对癌细胞的疗效。

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