L-半胱氨酸对青霉素类抗生素抗艰难梭菌活性的影响。
Effect of L-cysteine on the activity of penicillin antibiotics against Clostridium difficile.
作者信息
Markowitz S M, Williams D S
出版信息
Antimicrob Agents Chemother. 1985 Mar;27(3):419-21. doi: 10.1128/AAC.27.3.419.
Abstract
We observed elevated MICs of penicillin antibiotics while performing agar dilution susceptibility testing of strains of Clostridium difficile on supplemented brain heart infusion agar, an effect which was completely eliminated by the exclusion of L-cysteine from the medium. L-Cysteine antagonizes the activity of penicillins against C. difficile, most likely by direct inactivation of the antibiotic.
摘要
在对艰难梭菌菌株进行补充脑心浸液琼脂上的琼脂稀释药敏试验时，我们观察到青霉素类抗生素的最低抑菌浓度（MIC）升高，而从培养基中排除L-半胱氨酸后，这种影响完全消除。L-半胱氨酸拮抗青霉素对艰难梭菌的活性，很可能是通过直接使抗生素失活来实现的。
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