Xie Chunlin, Cheng Jiaheng, Chen Peng, Yan Xia, Luo Chenglong, Qu Hao, Shu Dingming, Ji Jian
State Key Laboratory of Swine and Poultry Breeding Industry Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences Guangzhou China.
Imeta. 2024 Dec 23;4(1):e264. doi: 10.1002/imt2.264. eCollection 2025 Feb.
This study explores the role of IgA-coated bacteria in improving feed efficiency in chickens, offering a novel perspective for probiotic screening. Chickens with high feed efficiency were found to have a greater abundance of Gram-positive bacteria, while low feed efficiency chickens exhibited higher levels of Gram-negative bacteria and potential pathogens. Through fecal microbiota transplantation (FMT) and integrating analysis of cecal and IgA-coated microbiota, we precisely identified as a key genus linked to improved feed efficiency. Further validation demonstrated that , a representative species of this genus, enhances feed efficiency and activates B cells to produce Immunoglobulin A (IgA), both in vivo and in vitro. Our findings provide new insights into the potential of IgA-coated bacteria as functional probiotics, offering a promising strategy for enhancing feed efficiency in animal production.
本研究探讨了IgA包被细菌在提高鸡饲料效率方面的作用，为益生菌筛选提供了新的视角。发现饲料效率高的鸡革兰氏阳性菌丰度更高，而饲料效率低的鸡革兰氏阴性菌和潜在病原体水平更高。通过粪便微生物群移植（FMT）以及盲肠和IgA包被微生物群的综合分析，我们精确鉴定出 为与提高饲料效率相关的关键属。进一步验证表明，该属的代表性物种 在体内和体外均能提高饲料效率并激活B细胞产生免疫球蛋白A（IgA）。我们的研究结果为IgA包被细菌作为功能性益生菌的潜力提供了新的见解，为提高动物生产中的饲料效率提供了一种有前景的策略。
