Serdarevic O, Darrell R W, Krueger R R, Trokel S L
Am J Ophthalmol. 1985 May 15;99(5):534-8. doi: 10.1016/s0002-9394(14)77952-8.
In vivo treatment of experimental Candida albicans keratitis with the excimer laser achieved sterilization on culture and histopathologically in all corneas in which clinically visible infiltration was removed with the laser at the 193-nm wavelength. Treatment at the 248-nm wavelength was not successful in eradicating infection compared with untreated controls. The 193-nm wavelength is highly effective, probably because infected tissue is totally removed by ablative photodecomposition. At the 248-nm wavelength, thermal effects become more dominant and, therefore, fungal elements are incompletely ablated. Light microscopy two days after treatment at the 193-nm wavelength showed healing of ulcerated areas, fine basophilic stippling at the epithelial-stromal interface, and undamaged underlying stroma.
用准分子激光对实验性白色念珠菌角膜炎进行体内治疗，在所有角膜中，用193纳米波长的激光去除临床上可见的浸润后，培养和组织病理学检查均实现了杀菌。与未治疗的对照组相比，248纳米波长的治疗未能成功根除感染。193纳米波长非常有效，可能是因为感染组织通过烧蚀光分解被完全去除。在248纳米波长下，热效应变得更加显著，因此真菌成分未被完全消融。193纳米波长治疗两天后的光学显微镜检查显示溃疡区域愈合，上皮-基质界面有细小的嗜碱性点彩，下方基质未受损。
