Wu Binhong, Zhou Zhinuo, Hong Xingwen, Xu Ziman, Xu Yuou, He Yushan, Chen Shu
School of Medicine & Nursing, Huzhou University, Huzhou, China.
The First Affiliated Hospital, Huzhou University, Huzhou, China.
J Oral Microbiol. 2025 Mar 6;17(1):2475947. doi: 10.1080/20002297.2025.2475947. eCollection 2025.
Enterococcus faecalis (), the main pathogenic bacterium of root canal infection, can penetrate deep into the dentin tubule, form a biofilm, and resist host defense mechanisms, thereby increasing treatment complexity. Therefore, the key to the treatment of root canal infections is to completely kill the bacteria and prevent secondary infection. This review assesses advancements in traditional and novel disinfection methods targeting biofilm.
By comparing the bactericidal mechanisms and effects of the individual and combined application of these methods, the scientific basis and clinical application potential of these methods as adjuvant or alternative treatments were evaluated and the scientific basis for the optimization of the root canal treatment strategy was provided.
Emerging strategies, including natural medicine, antibacterial photodynamic therapy, and cold atmospheric plasma, have shown promising antibacterial effects.
These approaches have the potential to replace traditional disinfection methods, offering more effective solutions for clinical pulp treatment.
粪肠球菌（）是根管感染的主要病原菌，可深入牙本质小管，形成生物膜，并抵抗宿主防御机制，从而增加治疗复杂性。因此，根管感染治疗的关键是彻底杀灭细菌并防止继发感染。本综述评估了针对生物膜的传统和新型消毒方法的进展。
通过比较这些方法单独应用和联合应用的杀菌机制及效果，评估这些方法作为辅助或替代治疗的科学依据及临床应用潜力，并为优化根管治疗策略提供科学依据。
包括天然药物、抗菌光动力疗法和低温大气等离子体在内的新兴策略已显示出有前景的抗菌效果。
这些方法有潜力取代传统消毒方法，为临床牙髓治疗提供更有效的解决方案。
