Weiller Cornelius, Reisert Marco, Levan Pierre, Hosp Jonas, Coenen Volker A, Rijntjes Michel
Department of Neurology and Clinical Neuroscience, Faculty of Medicine, University of Freiburg, Breisacherstrasse 64, D-79106 Freiburg i.Br., Germany.
Department of Medical Physics, Faculty of Medicine, University of Freiburg, Breisacherstrasse 64, D-79106 Freiburg i.Br., Germany.
Cereb Cortex. 2025 Mar 6;35(3). doi: 10.1093/cercor/bhaf035.
We must reconcile the needs of the internal world and the demands of the external world to make decisions relevant to homeostasis, well-being, and flexible behavior. Engagement with the internal (eg interoceptive) world is linked to medial brain systems, whereas the extrapersonal space (eg exteroceptive) is associated with lateral brain systems. Using Human Connectome Project data, we found three association tracts connecting the action-related frontal lobe with perception-related posterior lobes. A lateral dorsal tract and a medial dorsal tract interact independently with a ventral tract at frontal and posterior hubs. The two frontal and the two posterior hubs are interconnected, forming a meta-loop that integrates lateral and medial brain systems. The four anatomical hubs correspond to the common nodes of the intrinsic cognitive brain networks such as the default mode network. These functional networks depend on the integration of both realms. Thus, the positioning of functional cognitive networks can be understood as the intersection of long anatomical association tracts. The strength of structural connectivity within lateral and medial brain systems correlates with performance on behavioral tests assessing theory of mind. The meta-loop provides an anatomical framework to associate neurological and psychiatric symptoms with functional and structural changes.
我们必须协调内部世界的需求与外部世界的要求，以做出与内稳态、幸福感和灵活行为相关的决策。与内部（如内感受性）世界的互动与大脑内侧系统相关，而个人外部空间（如外感受性）则与大脑外侧系统相关。利用人类连接组计划的数据，我们发现了三条连接与动作相关的额叶和与感知相关的后叶的联合纤维束。一条外侧背侧纤维束和一条内侧背侧纤维束在额叶和后叶枢纽处与一条腹侧纤维束独立相互作用。两个额叶枢纽和两个后叶枢纽相互连接，形成一个整合大脑外侧和内侧系统的元回路。这四个解剖学枢纽对应于诸如默认模式网络等内在认知脑网络的共同节点。这些功能网络依赖于两个领域的整合。因此，功能性认知网络的定位可以理解为长解剖联合纤维束的交叉点。大脑外侧和内侧系统内结构连接的强度与评估心理理论的行为测试表现相关。这个元回路提供了一个解剖学框架，将神经和精神症状与功能和结构变化联系起来。
