Rajaei Seyedeh Niloufar, Darvish Mohammad, Zare Alireza, Abdollahi Hamed, Alivirdiloo Vahid, Hajiabbasi Mobasher, Ghazi Farhood, Mobed Ahmad
Faculty of Pharmacy, Friedrich Schiller University Jena, Jena, Germany.
School of Aerospace and Subaquatic Medicine, Infectious Diseases & Tropical Medicine Research Center(IDTMC), AJA University of Medical Sciences, Tehran, Iran.
J Clin Lab Anal. 2025 Apr;39(7):e70012. doi: 10.1002/jcla.70012. Epub 2025 Mar 13.
The recent rise in dengue virus (DENV) cases poses a significant threat to human health, with infections ranging from mild to severe and potentially leading to premature death.
To highlight the importance of early detection of DENV and to review advancements in detection technologies, particularly focusing on nanobiosensors.
This review examines traditional detection methods for DENV, including molecular, serological, and direct virus culture techniques, while discussing their limitations. It also explores innovative technologies that enhance detection accuracy, speed, and efficiency.
Nonstructural protein 1 (NS1) serves as a key biomarker present in high concentrations during the early stages of DENV infection, underscoring the need for timely detection. Traditional methods, while effective, have limitations that new technologies aim to address. Biosensors, particularly nanobiosensors, have emerged as promising tools for rapid, sensitive, and cost-effective DENV detection.
The adoption of advanced detection methods, especially nanobiosensors, is crucial for improving DENV management and reducing human suffering. This review provides a comprehensive overview of nanobiosensors and their applications, presented in an accessible manner for readers.
近期登革病毒（DENV）病例的增加对人类健康构成了重大威胁，感染程度从轻度到重度不等，甚至可能导致过早死亡。
强调早期检测登革病毒的重要性，并回顾检测技术的进展，尤其关注纳米生物传感器。
本综述考察了登革病毒的传统检测方法，包括分子、血清学和直接病毒培养技术，同时讨论了它们的局限性。还探讨了提高检测准确性、速度和效率的创新技术。
非结构蛋白1（NS1）是登革病毒感染早期高浓度存在的关键生物标志物，这突出了及时检测的必要性。传统方法虽然有效，但存在局限性，新技术旨在解决这些问题。生物传感器，尤其是纳米生物传感器，已成为快速、灵敏且经济高效地检测登革病毒的有前景的工具。
采用先进的检测方法，尤其是纳米生物传感器，对于改善登革病毒的管理和减轻人类痛苦至关重要。本综述以通俗易懂的方式全面概述了纳米生物传感器及其应用。
