Argüelles Juan-Carlos
Área de Microbiología, Facultad de Biología, Universidad de Murcia, 30100, Murcia, Spain.
Cell Mol Life Sci. 2025 Mar 17;82(1):120. doi: 10.1007/s00018-025-05650-8.
Since its discovery in the middle of the XX century, research into autophagy has undergone a spectacular expansion, particularly in the early 1990s. A number of physiological processes involving autophagy have been revealed and important human pathologies have been associated with perturbations in autophagy. In 2008 the "Guidelines for the use and interpretation of assays for monitoring autophagy" was launched with the purpose of collecting in a single document all the available information to monitor autophagy, which, it was thought, might be useful for established groups and any new scientists attracted by this field. The usefulness and success of this Guidelines has led to the subsequent publication of editions every 4 years, a task in which a growing number of authors have become involved and consequently included in the list of contributors. However, this worthy initiative and closely associated metric parameters has led to important scholarly repercussions in terms of perceived merits, grants and financial support obtained, professional careers and other areas concerning scientific activity. All these aspects are carefully examined in this contribution.
自20世纪中叶被发现以来，对自噬的研究经历了惊人的扩展，尤其是在20世纪90年代初。已经揭示了许多涉及自噬的生理过程，并且重要的人类病理学与自噬的扰动有关。2008年发布了《监测自噬的检测方法使用和解释指南》，目的是将所有可用于监测自噬的信息汇总在一份文件中，人们认为这可能对该领域的现有研究团队以及任何被该领域吸引的新科学家有用。本指南的实用性和成功促使其每4年发布一版，参与这项工作的作者越来越多，因此也被列入了贡献者名单。然而，这一有价值的举措以及与之密切相关的度量参数，在感知到的优点、获得的资助和资金支持、职业生涯以及与科学活动相关的其他领域方面，都产生了重要的学术影响。本论文将仔细审视所有这些方面。
