Palaniyappan Lena, Liddle Peter F
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, QC, Canada.
Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario London, ON, Canada.
Psychol Med. 2025 Mar 7;55:e75. doi: 10.1017/S0033291725000182.
We recall the life and work of Timothy J. Crow, whose contributions provided great insights into the pathophysiology of schizophrenia and continue to shape many questions in the field. We compile his key works relating to psychotic disorders, focusing on the trajectory of his theoretical stance. Our account is interlaced with our own interpretation of the evidence that influenced Crow's arguments over the years as well as his scientific method. Crow has had a significant impact on the neuroscience of schizophrenia. Many of his observations are still valid and several questions he raised remain unanswered to date.
我们回顾了蒂莫西·J·克劳的生平与工作,他的贡献为精神分裂症的病理生理学提供了深刻见解,并持续影响着该领域的诸多问题。我们汇编了他与精神障碍相关的重要著作,重点关注他理论立场的发展轨迹。我们的叙述穿插了我们自己对多年来影响克劳论点的证据以及他的科学方法的解读。克劳对精神分裂症神经科学产生了重大影响。他的许多观察结果至今仍然有效,他提出的一些问题至今仍未得到解答。