Trube Jennifer, Sabina Michael, Khanani Aqeel, Hernandez Kayla, Khan Zoya, Bizanti Anas
Lakeland Regional Health Medical Center, Lakeland, FL, USA.
Am Heart J Plus. 2025 Mar 8;52:100525. doi: 10.1016/j.ahjo.2025.100525. eCollection 2025 Apr.
Inflammation is a key risk factor in cardiovascular diseases, such as atherosclerosis, and has been linked to increased mortality following myocardial infarction. While inflammation promotes tissue repair, sustained inflammation can drive adverse cardiac remodeling, fibrosis, and impaired contractility, resulting in poorer outcomes. This maladaptive remodeling, compounded by oxidative stress, also predisposes patients to cardiovascular diseases. Colchicine has shown anti-inflammatory benefits in cardiovascular disease, but its role in individual diseases remains unclear. This literature review seeks to understand and evaluate the clinical trials evaluating colchicine in cardiovascular treatment.
A literature search identified randomized controlled trials (RCTs) evaluating colchicine in cardiovascular disease including coronary artery disease, post-myocardial infarction treatment, atrial fibrillation, heart failure, and stroke.
Colchicine has been studied across many cardiovascular conditions including atrial fibrillation (AF), coronary artery disease (CAD), post-myocardial infarction treatment, heart failure (HF) and stroke; however, evidence of its clinical effectiveness remains mixed. While colchicine has shown prfomise in reducing recurrent cardiovascular events in stable CAD, its impact in postoperative AF prevention, acute coronary syndrome (ACS), HF, and stroke prevention is limited.
炎症是心血管疾病（如动脉粥样硬化）的关键危险因素，且与心肌梗死后死亡率增加有关。虽然炎症促进组织修复，但持续的炎症会导致不良的心脏重塑、纤维化和收缩功能受损，从而导致更差的预后。这种由氧化应激加剧的适应性不良重塑也使患者易患心血管疾病。秋水仙碱已显示出对心血管疾病具有抗炎作用，但其在个别疾病中的作用仍不明确。这篇文献综述旨在了解和评估评价秋水仙碱在心血管治疗中的临床试验。
文献检索确定了评估秋水仙碱在心血管疾病（包括冠状动脉疾病、心肌梗死后治疗、心房颤动、心力衰竭和中风）中的随机对照试验（RCT）。
秋水仙碱已在许多心血管疾病中进行了研究，包括心房颤动（AF）、冠状动脉疾病（CAD）、心肌梗死后治疗、心力衰竭（HF）和中风；然而，其临床有效性的证据仍然不一。虽然秋水仙碱在降低稳定型CAD的心血管事件复发方面显示出前景，但其在预防术后AF、急性冠状动脉综合征（ACS）、HF和中风方面的影响有限。
