• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用 合成的氧化锌纳米颗粒对耐碳青霉烯类抗生素的 和 的影响。

Effects of Zinc Oxide Nanoparticles Synthesized Using on Carbapenem-Resistant and .

机构信息

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

出版信息

Front Cell Infect Microbiol. 2021 Nov 16;11:748739. doi: 10.3389/fcimb.2021.748739. eCollection 2021.

DOI:10.3389/fcimb.2021.748739
PMID:34869059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8635236/
Abstract

Currently, the mortality rate in Saudi Arabia's ICUs is increasing due to the spread of carbapenemase (KPC)-producing bacteria. This study was carried out to evaluate the ability of biologically synthesized zinc oxide nanoparticles (ZnO-NPs) using to overcome carbapenem-resistant (KPC) and . ZnO-NPs were synthesized a biological method and characterized using UV-Vis spectroscopy, Zetasizer and zeta potential analyses, x-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), and energy-dispersive x-ray spectroscopy (EDX). sensitivity of KPC to ZnO-NPs was identified using the well diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by a macro-dilution method. The morphological alteration of KPC cells after ZnO-NPs treatment was observed by SEM. The susceptibility of KPC cells to ZnO-NPs ointment was evaluated using wound healing in experimental rats. The chemical characterization findings showed the formation, stability, shape, and size of the synthesized nanoparticles. The MIC and MBC were 0.7 and 1.8 mg/ml, respectively. The results displayed reduced inflammation and wound re-epithelialization of KPC-infected rats. These findings demonstrated that ZnO-NPs have great potential to be developed as antibacterial agents.

摘要

目前，由于碳青霉烯酶（KPC）产生菌的传播，沙特阿拉伯 ICU 的死亡率正在上升。本研究旨在评估使用生物合成的氧化锌纳米粒子（ZnO-NPs）来克服耐碳青霉烯的（KPC）和的能力。ZnO-NPs 通过生物方法合成，并使用紫外-可见分光光度法、Zetasizer 和 ζ 电位分析、X 射线衍射光谱、傅里叶变换红外光谱、扫描电子显微镜（SEM）和能谱（EDX）进行表征。使用井扩散法鉴定 KPC 对 ZnO-NPs 的敏感性。通过宏观稀释法确定最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。通过 SEM 观察 ZnO-NPs 处理后 KPC 细胞的形态变化。使用实验大鼠的伤口愈合评估 KPC 细胞对 ZnO-NPs 软膏的敏感性。化学特性研究结果表明合成纳米粒子的形成、稳定性、形状和尺寸。MIC 和 MBC 分别为 0.7 和 1.8 mg/ml。结果显示，KPC 感染大鼠的炎症减轻，伤口再上皮化。这些发现表明 ZnO-NPs 具有很大的潜力可开发为抗菌剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/a79035e179ef/fcimb-11-748739-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/82479a8134a1/fcimb-11-748739-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/06bae2050e94/fcimb-11-748739-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/2df16254bd4d/fcimb-11-748739-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/f7d90705cd0e/fcimb-11-748739-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/450dbef2beea/fcimb-11-748739-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/5b7209cbc053/fcimb-11-748739-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/eff6b6e17c8d/fcimb-11-748739-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/6912cab07d60/fcimb-11-748739-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/a79035e179ef/fcimb-11-748739-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/82479a8134a1/fcimb-11-748739-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/06bae2050e94/fcimb-11-748739-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/2df16254bd4d/fcimb-11-748739-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/f7d90705cd0e/fcimb-11-748739-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/450dbef2beea/fcimb-11-748739-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/5b7209cbc053/fcimb-11-748739-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/eff6b6e17c8d/fcimb-11-748739-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/6912cab07d60/fcimb-11-748739-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edb2/8635236/a79035e179ef/fcimb-11-748739-g009.jpg

相似文献

1
Effects of Zinc Oxide Nanoparticles Synthesized Using on Carbapenem-Resistant and .利用 合成的氧化锌纳米颗粒对耐碳青霉烯类抗生素的 和 的影响。
Front Cell Infect Microbiol. 2021 Nov 16;11:748739. doi: 10.3389/fcimb.2021.748739. eCollection 2021.
2
Biosynthesis of Zinc Oxide Nanoparticles from (L.) Extract to Overcome Carbapenem-Resistant .利用（L.）提取物生物合成氧化锌纳米颗粒以克服耐碳青霉烯类[细菌]
Molecules. 2021 Mar 29;26(7):1919. doi: 10.3390/molecules26071919.
3
Molecular Dynamic Analysis of Carbapenem-Resistant 's Porin Proteins with Beta Lactam Antibiotics and Zinc Oxide Nanoparticles.碳青霉烯类耐药“孔蛋白”与β-内酰胺类抗生素和氧化锌纳米粒子的分子动力学分析。
Molecules. 2023 Mar 9;28(6):2510. doi: 10.3390/molecules28062510.
4
Mycogenic Synthesis of Extracellular Zinc Oxide Nanoparticles from and Its Nanoantibiotic Potential.从 中合成细胞外氧化锌纳米粒子及其纳米抗生素潜力的真菌合成。
Int J Nanomedicine. 2020 Nov 2;15:8519-8536. doi: 10.2147/IJN.S271743. eCollection 2020.
5
Antimicrobial activity of zinc oxide (ZnO) nanoparticle against Klebsiella pneumoniae.氧化锌纳米颗粒对肺炎克雷伯菌的抗菌活性。
Pharm Biol. 2014 Nov;52(11):1388-97. doi: 10.3109/13880209.2014.893001. Epub 2014 Jul 15.
6
Phyto-mediated synthesis of zinc oxide nanoparticles of Berberis aristata: Characterization, antioxidant activity and antibacterial activity with special reference to urinary tract pathogens.植物介导的小檗中氧化锌纳米粒子的合成：特性、抗氧化活性和抗菌活性，特别是针对尿路感染病原体。
Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:212-220. doi: 10.1016/j.msec.2019.04.035. Epub 2019 Apr 13.
7
Phytochemical fabrication of ZnO nanoparticles and their antibacterial and anti-biofilm activity.植物化学法制备 ZnO 纳米粒子及其抗菌和抗生物膜活性。
Sci Rep. 2024 Aug 24;14(1):19714. doi: 10.1038/s41598-024-69044-9.
8
Green synthesis of zinc oxide nanoparticles using novel bacterium strain (Bacillus subtilis NH1-8) and their in vitro antibacterial and antibiofilm activities against Salmonellatyphimurium.利用新型菌株（枯草芽孢杆菌 NH1-8）合成氧化锌纳米粒子及其对鼠伤寒沙门氏菌的体外抗菌和抗生物膜活性。
Microb Pathog. 2023 Dec;185:106457. doi: 10.1016/j.micpath.2023.106457. Epub 2023 Nov 21.
9
Spectrophotometrically, Spectroscopically, Microscopically and Thermogravimetrically Optimized TiO and ZnO Nanoparticles and their Bactericidal, Antioxidant and Cytotoxic Potential: A Novel Comparative Approach.分光光度法、光谱法、显微镜法和热重分析法优化的二氧化钛和氧化锌纳米颗粒及其杀菌、抗氧化和细胞毒性潜力：一种新型比较方法。
J Fluoresc. 2024 Sep;34(5):2019-2033. doi: 10.1007/s10895-023-03367-0. Epub 2023 Sep 6.
10
Green synthesised zinc oxide nanoparticles reveal potent in vivo and in vitro antibacterial efficacy against Proteus mirabilis isolates.绿色合成氧化锌纳米粒子对奇异变形杆菌分离株表现出强大的体内和体外抗菌功效。
Int J Pharm. 2023 Jul 25;642:123111. doi: 10.1016/j.ijpharm.2023.123111. Epub 2023 Jun 10.

引用本文的文献

1
Antibacterial impact of biosynthesized zinc oxide nanoparticles on uropathogenic Escherichia coli and in vivo assessment of physiological and histological alterations.生物合成氧化锌纳米颗粒对尿路致病性大肠杆菌的抗菌作用以及生理和组织学改变的体内评估
Sci Rep. 2025 May 5;15(1):15721. doi: 10.1038/s41598-025-98060-6.
2
A Comprehensive Overview of : Resistance Dynamics, Clinical Manifestations, and Therapeutic Options.《耐药动态、临床表现及治疗选择综述》
Infect Drug Resist. 2025 Mar 25;18:1611-1628. doi: 10.2147/IDR.S502175. eCollection 2025.
3
Bidah Pomegranate Landrace: Chemical Composition, Antioxidant, Antibacterial, and Anticancer Activity.

本文引用的文献

1
Biosynthesis of Zinc Oxide Nanoparticles from (L.) Extract to Overcome Carbapenem-Resistant .利用（L.）提取物生物合成氧化锌纳米颗粒以克服耐碳青霉烯类[细菌]
Molecules. 2021 Mar 29;26(7):1919. doi: 10.3390/molecules26071919.
2
Green Synthesis of Zinc Oxide Nanoparticles from Pomegranate () Extracts and Characterization of Their Antibacterial Activity.石榴（）提取物合成氧化锌纳米粒子及其抗菌活性的表征。
Molecules. 2020 Oct 2;25(19):4521. doi: 10.3390/molecules25194521.
3
Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications.
比达石榴地方品种：化学成分、抗氧化、抗菌和抗癌活性。
Life (Basel). 2025 Mar 18;15(3):489. doi: 10.3390/life15030489.
4
Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review.氧化锌纳米颗粒的绿色合成：制备、表征及生物医学应用——综述
Int J Nanomedicine. 2024 Dec 3;19:12889-12937. doi: 10.2147/IJN.S487188. eCollection 2024.
5
Arthrospira maxima and biosynthesized zinc oxide nanoparticles as antibacterials against carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii: a review article.最大螺旋藻和生物合成氧化锌纳米粒子作为抗碳青霉烯类耐药肺炎克雷伯菌和鲍曼不动杆菌的抗菌剂：综述文章。
Microb Cell Fact. 2024 Nov 19;23(1):311. doi: 10.1186/s12934-024-02584-x.
6
Investigating the in vitro antibacterial, antibiofilm, antioxidant, anticancer and antiviral activities of zinc oxide nanoparticles biofabricated from Cassia javanica.研究从决明子生物合成的氧化锌纳米粒子的体外抗菌、抗生物膜、抗氧化、抗癌和抗病毒活性。
PLoS One. 2024 Oct 1;19(10):e0310927. doi: 10.1371/journal.pone.0310927. eCollection 2024.
7
Antifungal activity of fruit extract against : and study.水果提取物对……的抗真菌活性及研究
Front Microbiol. 2024 May 13;15:1399671. doi: 10.3389/fmicb.2024.1399671. eCollection 2024.
8
Catharanthus roseus-assisted bio-fabricated zinc oxide nanoparticles for promising antibacterial potential against Klebsiella pneumoniae.长春花辅助生物合成氧化锌纳米粒子对肺炎克雷伯菌具有有前景的抗菌潜力。
Bioprocess Biosyst Eng. 2024 Aug;47(8):1259-1269. doi: 10.1007/s00449-024-03001-8. Epub 2024 Mar 25.
9
The impact and safety of encapsulated nanomaterials as a new alternative against carbapenem resistant bacteria. a systematic review.作为一种新的针对耐碳青霉烯类抗生素细菌的替代物，封装纳米材料的影响和安全性：系统评价。
World J Microbiol Biotechnol. 2024 Jan 18;40(2):72. doi: 10.1007/s11274-024-03894-3.
10
mediated biosynthesis of nanoparticles and biofortification.纳米颗粒的介导生物合成与生物强化
Food Sci Biotechnol. 2023 Apr 26;32(14):2079-2092. doi: 10.1007/s10068-023-01307-z. eCollection 2023 Dec.
绿色合成氧化锌纳米粒子：特性与多方面应用。
Molecules. 2020 Sep 14;25(18):4198. doi: 10.3390/molecules25184198.
4
Preparation and Evaluation of the ZnO NP-Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities.氧化锌纳米粒子-氨苄西林/舒巴坦纳米抗生素的制备与评价：利用 RSM 结合 GA 方法优化制剂变量及抗菌活性。
Biomolecules. 2019 Nov 21;9(12):764. doi: 10.3390/biom9120764.
5
Carbapenem-Resistant Enterobacteriaceae: An update narrative review from Saudi Arabia.耐碳青霉烯肠杆菌科：来自沙特阿拉伯的更新叙述性综述。
J Infect Public Health. 2019 Jul-Aug;12(4):465-471. doi: 10.1016/j.jiph.2019.03.024. Epub 2019 May 3.
6
A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae.一种高通量、全细胞检测方法，用于鉴定针对耐碳青霉烯类肺炎克雷伯菌的活性化合物。
PLoS One. 2018 Dec 21;13(12):e0209389. doi: 10.1371/journal.pone.0209389. eCollection 2018.
7
Exploiting potential and characterization of surface modified Zinc oxide nanoparticles of extract: Their clinical potential towards HepG2 cell line and human pathogenic bacteria.提取物表面改性氧化锌纳米颗粒的潜力开发与表征：它们对肝癌细胞系和人类病原菌的临床潜力
EXCLI J. 2018 Jul 16;17:671-687. doi: 10.17179/excli2018-1327. eCollection 2018.
8
Mechanism of Anti-bacterial Activity of Zinc Oxide Nanoparticle Against Carbapenem-Resistant .氧化锌纳米颗粒对耐碳青霉烯类细菌的抗菌活性机制
Front Microbiol. 2018 Jun 6;9:1218. doi: 10.3389/fmicb.2018.01218. eCollection 2018.
9
Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium in dermally-wounded rats.评估 Brevinin-2Ta 对皮肤创伤大鼠体内细菌的抗菌及伤口愈合作用。
Oncotarget. 2017 Nov 30;8(67):111369-111385. doi: 10.18632/oncotarget.22797. eCollection 2017 Dec 19.
10
Carbapenem-resistant Enterobacteriaceae in the community: a scoping review.社区获得性耐碳青霉烯肠杆菌科细菌：范围综述。
Int J Antimicrob Agents. 2017 Aug;50(2):127-134. doi: 10.1016/j.ijantimicag.2017.03.012. Epub 2017 Jun 21.