久坐行为与全身免疫炎症指数及全身炎症反应指数水平相关：2011 - 2018年美国国家健康与营养检查调查的横断面分析
Sedentary behavior is associated with systemic immune-inflammation index and systemic inflammation response index levels: a cross-sectional analysis of the NHANES 2011-2018.
作者信息
Wu Xian, Zhong Lin, Hu Yuehong, Ruan Lingying, Zhou Kaiyu, Liu Hanmin, Chen Lina
机构信息
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Division of Pediatric Pulmonology and Immunology, NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Front Public Health. 2025 Mar 19;13:1431065. doi: 10.3389/fpubh.2025.1431065. eCollection 2025.
BACKGROUND
Sedentary behavior (SB), has been closely linked to numerous detrimental health effects. While the individual and combined impacts of such behaviors on immune-inflammatory responses remain ambiguous, innovative indices like the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI) are considered as comprehensive tools to assess inflammation. This study endeavors to elucidate the potential correlations between SB, SII, and SIRI, thereby contributing to a deeper understanding of how lifestyle choices influence systemic inflammation profiles.
METHODS
This research entailed a retrospective, cross-sectional examination of 39,156 adult participants sourced from 2011 to 2018 of the National Health and Nutrition Examination Survey (NHANES). SASB was used as the independent variable and SII and SIRI as dependent variables. Weighted linear regression was used to assess the correlation between the independent and dependent variables. Smoothed curve fitting and threshold effect analyses were also performed to determine to identify if there was a non-linear relationship between SII and SIRI and SASB. Subgroup analyses were then performed to identify sensitive populations.
RESULTS
A total of 15,789 individuals ≥18 years old were included. Elevated SB levels were correlated with a rise in SII levels in three models ( < 0.05). There was a positive correlation of SB and SII (as a continuous variable). At the same, higher SB was associated with increased SIRI level in three models ( < 0.05). However, there was a non-linear correlation between SB and SIRI with 485 min (min) being the inflection point.
CONCLUSION
Among US adults, SII and SIRI exhibited a positive correlation with heightened SB, underscoring the need for more extensive, prospective studies to further elucidate SB's impact on these inflammation indices.
背景
久坐行为（SB）与众多有害健康影响密切相关。虽然此类行为对免疫炎症反应的个体及综合影响仍不明确，但诸如全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）等创新指标被视为评估炎症的综合工具。本研究旨在阐明SB、SII和SIRI之间的潜在关联，从而有助于更深入地理解生活方式选择如何影响全身炎症特征。
方法
本研究对2011年至2018年美国国家健康与营养检查调查（NHANES）中的39156名成年参与者进行了回顾性横断面研究。将久坐行为（SASB）用作自变量，SII和SIRI用作因变量。采用加权线性回归评估自变量与因变量之间的相关性。还进行了平滑曲线拟合和阈值效应分析，以确定SII、SIRI与SASB之间是否存在非线性关系。随后进行亚组分析以识别敏感人群。
结果
共纳入15789名年龄≥18岁的个体。在三个模型中，久坐行为水平升高与SII水平升高相关（<0.05）。久坐行为与SII呈正相关（作为连续变量）。同时，在三个模型中，较高的久坐行为与SIRI水平升高相关（<0.05）。然而，久坐行为与SIRI之间存在非线性相关性，拐点为485分钟（min）。
结论
在美国成年人中，SII和SIRI与久坐行为增加呈正相关，这突出表明需要进行更广泛的前瞻性研究，以进一步阐明久坐行为对这些炎症指标的影响。
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