Price K R, Fenwick G R
Food Addit Contam. 1985 Apr-Jun;2(2):73-106. doi: 10.1080/02652038509373531.
This review is concerned with the presence of naturally occurring oestrogens in food plants and processed foods. Particular emphasis is placed on isoflavones and coumestans, both of which are true plant oestrogens, and the resorcylic acid lactones, more correctly classified as fungal oestrogens. The metabolism and mode of action of these compounds is discussed and their biological potencies, determined in both in vivo and in vitro studies, described. Current methods of analysis are indicated and the levels of these oestrogens in food plants, processed foods and foodstuffs are presented. Botanical, environmental or technological factors affecting the possible intake of plant and fungal oestrogens are mentioned and the hazard associated with such intake is compared with that originating from other dietary or medicinal hormonally active substances. Indications are given of the wide range of common food plants which have been reported to possess oestrogenic (uterotropic) activity, although it is emphasized that in general further work is necessary to substantiate these claims and to confirm the identities of the biologically active principles which have in some cases been proposed. In the concluding section suggestions are made for additional research considered important or necessary in this interesting area.
本综述关注食用植物和加工食品中天然存在的雌激素。特别强调了异黄酮和香豆雌酚，这两种都是真正的植物雌激素，以及雷琐酸内酯，更准确地归类为真菌雌激素。讨论了这些化合物的代谢和作用方式，并描述了它们在体内和体外研究中确定的生物活性。指出了当前的分析方法，并列出了这些雌激素在食用植物、加工食品和食品中的含量。提及了影响植物和真菌雌激素可能摄入量的植物学、环境或技术因素，并将这种摄入相关的危害与其他饮食或药用激素活性物质产生的危害进行了比较。指出了据报道具有雌激素（促子宫生长）活性的多种常见食用植物，不过强调一般而言，需要进一步开展工作来证实这些说法，并确认在某些情况下所提出的生物活性成分的身份。在结论部分，针对这一有趣领域中被认为重要或必要的额外研究提出了建议。
