Meng Chenchen, Li Bei, Wang Zhaoxia, Peng Qing
Neurology Department, Peking University First Hospital, Beijing, China.
Front Nutr. 2025 Mar 28;12:1545951. doi: 10.3389/fnut.2025.1545951. eCollection 2025.
Alzheimer's disease (AD) is a severe neurodegenerative disorder. Nutritional management has been recognized as a potential therapeutic approach to mitigate AD progression. This study aimed to analyze the bibliometric characteristics and research trends of publications on nutritional management in AD.
A systematic search was conducted on the Web of Science Core Collection database to identify publications related to nutritional management in AD from 1988 to 2024. Bibliometric analysis was performed using VOSviewers (V 1.6.20), CiteSpace (V 6.3.R1) and R 4.3.3.
A total of 554 publications from 311 countries led by the USA were identified. The number of publications has increased annually. The most cited article discussed the role of diet in providing antioxidants to combat oxidative stress in neurodegenerative diseases. The University of California system published the most articles, and Rush University had the most international collaborations. These publications came from 3,298 authors, among which Mattson MP had the highest total publications and citations. The published the most articles and received the most citations. Keywords analysis revealed evolving trends, with early emphasis on "precursor protein" and later shifts to "dietary restriction," and more recently, "insulin resistance" and "synaptic plasticity." Emerging keywords include "obesity," "cognitive impairment" and "association."
This study represents the first summary of research trends in AD nutritional management. Future research is likely to focus on the associations between nutrition, insulin resistance, synaptic plasticity, and cognitive impairment in AD patients. This information provides valuable insights for scholars and practitioners in the field.
阿尔茨海默病（AD）是一种严重的神经退行性疾病。营养管理已被认为是减缓AD进展的一种潜在治疗方法。本研究旨在分析AD营养管理相关出版物的文献计量学特征和研究趋势。
在科学网核心合集数据库中进行系统检索，以确定1988年至2024年期间与AD营养管理相关的出版物。使用VOSviewer（V 1.6.20）、CiteSpace（V 6.3.R1）和R 4.3.3进行文献计量分析。
共确定了来自311个国家以美国为首的554篇出版物。出版物数量逐年增加。被引用次数最多的文章讨论了饮食在提供抗氧化剂以对抗神经退行性疾病中的氧化应激方面的作用。加利福尼亚大学系统发表的文章最多，拉什大学的国际合作最多。这些出版物来自3298位作者，其中马特森·MP的总出版物和被引用次数最高。发表的文章最多且被引用次数最多。关键词分析揭示了不断变化的趋势，早期重点是“前体蛋白”，后来转向“饮食限制”，最近则是“胰岛素抵抗”和“突触可塑性”。新兴关键词包括“肥胖”、“认知障碍”和“关联”。
本研究是AD营养管理研究趋势的首次总结。未来的研究可能会集中在AD患者营养、胰岛素抵抗、突触可塑性和认知障碍之间的关联上。这些信息为该领域的学者和从业者提供了有价值的见解。
