Anticancer and Antioxidant Activities of Rhizospheric Soil Bacteria of .

Identification of new sources of compounds with anticancer and antioxidant potential is essential for cancer treatment. Rhizospheric bacteria have emerged as a promising source of these agents. This study is aimed at investigating the anticancer and antioxidant properties of bacteria isolated from the rhizosphere of . Six rhizobacteria of were isolated and molecularly identified by sequencing the 16S rRNA gene and MALDI-TOF. We evaluated the inhibitory activity of methanol (MeOH) and ethyl acetate (EtOAc) extracts obtained from rhizobacteria against the murine lymphoma cell line L5178Y-R, as well as normal Vero monkey kidney cells and peripheral blood mononuclear cells (PBMCs). Compared with those of normal cells, the MeOH extract of sp. PMS-B023 showed selective anticancer activity against lymphoma, with 50% inhibitory concentration (IC) values of 117.5 g/mL and a selectivity index (SI) > 2.1, as compared with those of normal cells. L-Pro-L-Val cycle, gageostatin B, cinnamic acid, parvifloracin, daidzein, genistein, actinomycin D, actinomycin Y4, and surfactin C were detected in the MeOH extract, which may be responsible for its antilymphoma activity. We did not find significant antioxidant activity in any of the extracts evaluated using the 2,2-diphenyl-1-picrylhydrazyl technique (IC > 250 g/mL). The results showed that sp. PMS-B023 has antitumor potential and selective activity against L5178Y-R lymphoma cells. The presence of anticancer compounds was also demonstrated, as previously described in the literature.