Ortiz Oswaldo, Sendino Oriol, Rivadulla Silvia, Garrido Alejandra, Neira Luz María, Sanahuja Josep, Sesé Pilar, Guardiola Marta, Fernández-Esparrach Glòria
Endoscopy Unit, Hospital Clínic, University of Barcelona (UB), 08036 Barcelona, Spain.
Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Cancers (Basel). 2025 Mar 22;17(7):1073. doi: 10.3390/cancers17071073.
: Colonoscopies have some limitations that result in a miss rate detection of polyps. Microwave imaging has been demonstrated to detect colorectal polyps based on their dielectric properties in synthetic phantoms, ex vivo tissues and in vivo animal models. This study aims to evaluate, for the first time, the feasibility, safety and performance of microwave-based colonoscopy for diagnosis of polyps in real-time explorations in humans. : This was a single-center, prospective, observational study. Patients referred for diagnostic colonoscopy were explored with a device with microwave antennas which was attached to the tip of a standard colonoscope. The primary outcomes were rate of cecal intubation, adverse events, mural injuries and performance metrics for the detection of polyps. Secondary outcomes were the following: patients' subjective feedback, procedural time and perception of difficulty according to the endoscopist. : Fifteen patients were enrolled. Cecal intubation rate was 100%, with a mean time of 12.7 ± 4.9 min (range 4-22). Use of the device did not affect the endoscopic image, and polypectomy was successfully performed in all cases. In on scale from zero (not difficult) to four (very difficult), the maneuverability during the insertion was considered ≤2 in the 86.7% (13/15) of colonoscopies. Only 16 incidents were reported in 14 patients: 11 (67%) superficial hematomas, 2 minor rectal bleedings, 1 anal fissure, 1 rhinorrhea and 1 headache. Most of the patients (94%) reported no discomfort or minimal discomfort before discharge (Gloucester score 1 and 2, respectively). In the six patients with 23 polyps used for the performance analysis, the sensitivity and specificity were 86.9% and 72.0%, respectively. : microwave-based colonoscopy is safe and feasible and has the potential to detect polyps in real colonoscopies.
结肠镜检查存在一些局限性，导致息肉检测存在漏诊率。微波成像已被证明可基于其在合成体模、离体组织和体内动物模型中的介电特性来检测结直肠息肉。本研究旨在首次评估基于微波的结肠镜检查在人体实时探查中诊断息肉的可行性、安全性和性能。
这是一项单中心、前瞻性、观察性研究。对因诊断性结肠镜检查而转诊的患者，使用一种带有微波天线的设备进行探查，该设备附着在标准结肠镜的尖端。主要结局指标为盲肠插管率、不良事件、肠壁损伤以及息肉检测的性能指标。次要结局指标如下：患者的主观反馈、操作时间以及内镜医师对操作难度的感知。
共纳入15例患者。盲肠插管率为100%，平均时间为12.7±4.9分钟（范围4 - 22分钟）。该设备的使用不影响内镜图像，所有病例均成功进行了息肉切除术。在从0（不难）到4（非常难）的评分量表中，86.7%（13/15）的结肠镜检查中插入过程的可操作性被认为≤2。14例患者仅报告了16起事件：11例（67%）为浅表血肿、2例轻度直肠出血、1例肛裂、1例鼻漏和1例头痛。大多数患者（94%）在出院前报告无不适或仅有轻微不适（分别为格洛斯特评分1分和2分）。在用于性能分析的6例有23个息肉的患者中，敏感性和特异性分别为86.9%和72.0%。
基于微波的结肠镜检查是安全可行的，并且有潜力在实际结肠镜检查中检测息肉。
