Krause U, Ejerblad S, Bergman L
Scand J Gastroenterol. 1985 May;20(4):516-24. doi: 10.3109/00365528509089690.
A series of 186 patients treated for Crohn's disease during the period 1956 to 1968 has been followed up in 1970, 1975, and now in 1983. Among 173 patients operated on there were 89 recurrences (52%). After a follow-up time greater than 14 years (mean, 18 years) 'radical' resections at the first operation gave a lower recurrence rate (31%), fewer reoperations, and a better quality of life compared with non-'radical' resections (recurrence rate, 83%). The quality of life estimated for all patients alive in 1983, 152 patients, was good in 89%; 8.6% had moderate subjective symptoms, and 2.6% had pronounced subjective symptoms. With an increasing follow-up time there was no decrease in the patients' quality of life. Ileorectal anastomosis did not give very good results; proctocolectomy and ileostomy, however, gave good results. Regular investigation of all patients is of vital importance to give them a good quality of life.
1956年至1968年期间接受克罗恩病治疗的186例患者，于1970年、1975年以及现在的1983年进行了随访。在173例接受手术的患者中，有89例复发（52%）。在随访时间超过14年（平均18年）后，首次手术时进行“根治性”切除的患者复发率较低（31%），再次手术较少，与非“根治性”切除（复发率83%）相比生活质量更好。对1983年仍存活的所有152例患者进行的生活质量评估显示，89%的患者生活质量良好；8.6%的患者有中度主观症状，2.6%的患者有明显主观症状。随着随访时间的延长，患者的生活质量并未下降。回直肠吻合术效果不太理想；然而，全直肠结肠切除术和回肠造口术效果良好。对所有患者进行定期检查对于给予他们良好的生活质量至关重要。
